LDL 受体及其在脑胶质瘤靶向治疗中的作用：综述。
LDL receptors and their role in targeted therapy for glioma: a review.
机构信息
Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Troy High School, Troy, MI 48098, USA.
Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Walled Lake Central High School, Commerce Charter Township, MI 48390, USA.
出版信息
Drug Discov Today. 2021 May;26(5):1212-1225. doi: 10.1016/j.drudis.2021.02.008. Epub 2021 Feb 18.
Gliomas are highly lethal forms of cancers occurring in the brain. Delivering the drugs into the brain is a major challenge to the treatment of gliomas because of the highly selectively permeable blood-brain barrier (BBB). Tapping the potential of receptor-mediated drug delivery systems using targeted nanoparticles (NPs) is a sought-after step forward toward successful glioma treatment. Several receptors are the focus of research for application in drug delivery. Low-density lipoprotein receptors (LDLR) are abundantly expressed in both healthy brains and diseased brains with a disrupted BBB. In this review, we discuss the LDLR and the types of NPs that have been used to target the brain via this receptor.
神经胶质瘤是一种发生在大脑中的高度致命性癌症。由于血脑屏障（BBB）具有高度选择性通透性，因此将药物递送到大脑是治疗神经胶质瘤的主要挑战。利用靶向纳米颗粒（NPs）的受体介导药物传递系统的潜力是实现成功治疗神经胶质瘤的重要一步。有几种受体是药物传递应用研究的重点。低密度脂蛋白受体（LDLR）在健康大脑和 BBB 破坏的患病大脑中均大量表达。在这篇综述中，我们讨论了 LDLR 以及已被用于通过该受体靶向大脑的各种 NPs。
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