纳米递药系统在血脑屏障（BBB）穿透和脑肿瘤靶向治疗方面的最新进展。
Recent advances in nano delivery systems for blood-brain barrier (BBB) penetration and targeting of brain tumors.
机构信息
Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Northville High School, Northville, MI 48168, USA.
Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
出版信息
Drug Discov Today. 2021 Aug;26(8):1944-1952. doi: 10.1016/j.drudis.2021.04.008. Epub 2021 Apr 16.
Gliomas constitute about 80% of brain tumors and have a meager two-year survival rate. The treatment options available are very few because of poor prognosis and a lack of targeted nanodelivery systems that can cross the blood-brain barrier (BBB) and the blood-tumor barrier. This short review attempts to clarify the challenges for delivery systems designed to cross the BBB, and provides a brief description of the different types of targeted nanodelivery system that have shown potential for success in delivering drugs to the brain. Further, this review describes the most recent studies that have developed nanoparticles for brain delivery in the past five years. We also provide an insight into the most recent clinical trials designed to assess the efficacy of these nanodelivery systems for glioma.
神经胶质瘤约占脑肿瘤的 80%，其两年生存率很低。由于预后不良和缺乏能够穿过血脑屏障（BBB）和血肿瘤屏障的靶向纳米递药系统，可用的治疗选择非常有限。本文简短综述旨在阐明用于穿越 BBB 的递药系统所面临的挑战，并简要介绍了在将药物递送到脑部方面显示出成功潜力的不同类型的靶向纳米递药系统。此外，本文还描述了过去五年中为脑部递药而开发纳米颗粒的最新研究。我们还深入探讨了旨在评估这些纳米递药系统治疗脑胶质瘤疗效的最新临床试验。
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