Gong Mancheng, Song Erlin, Huang Guiying, Ni Wenjun, Dong Wenjing, Yuan Runqiang
Department of Urology, The People's Hospital of Zhongshan, Zhongshan, China.
Department of Urology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Front Genet. 2021 Feb 3;12:579900. doi: 10.3389/fgene.2021.579900. eCollection 2021.
Bladder cancer is one of the most common urogenital malignancies in the world, and there are no adequate prognostic indicators. is one of the atypical cyclins, which may be related to the cell cycle and even the development of cancers. Early studies have shown that is closely related to the occurrence and development of many malignant tumors. However, the mechanism of in bladder cancer has not been reported. In our research, we explored the different expressions of between 411 bladder cancers and 19 normal bladder tissues based on the TCGA dataset. -related signaling pathways were identified through the GSEA. We analyzed the associations of expression and bladder cancer progression and survival using GSE13507. Compared with 19 cases of normal bladder tissue, gene expression was increased in 411 cases of bladder cancer. The high expression of strongly correlated with grade ( < 0.0001), T classification ( = 0.0001), N classification ( = 0.00011), M classification ( = 0.044), age ( = 0.027), and gender ( = 0.0012). Bladder cancer patients with high expression had shorter overall survival ( < 0.001). In the meantime, univariate and multivariate analyses showed that the increased expression of was an independent factor for poor prognosis in bladder cancer patients ( < 0.001 and < 0.001, respectively). expression is closely related to bladder cancer progression, and the high expression of may be an adverse biomarker in bladder cancer patients.
膀胱癌是世界上最常见的泌尿生殖系统恶性肿瘤之一，目前尚无充分的预后指标。 是一种非典型细胞周期蛋白，可能与细胞周期甚至癌症的发生发展有关。早期研究表明， 与许多恶性肿瘤的发生发展密切相关。然而， 在膀胱癌中的作用机制尚未见报道。在我们的研究中，我们基于TCGA数据集探讨了411例膀胱癌组织和19例正常膀胱组织中 的表达差异。通过基因集富集分析（GSEA）确定了与 相关的信号通路。我们使用GSE13507分析了 表达与膀胱癌进展及生存的相关性。与19例正常膀胱组织相比，411例膀胱癌组织中 基因表达升高。 的高表达与肿瘤分级（ < 0.0001）、T分期（ = 0.0001）、N分期（ = 0.00011）、M分期（ = 0.044）、年龄（ = 0.027）和性别（ = 0.0012）密切相关。 高表达的膀胱癌患者总生存期较短（ < 0.001）。同时，单因素和多因素分析显示， 表达增加是膀胱癌患者预后不良的独立因素（分别为 < 0.001和 < 0.001）。 表达与膀胱癌进展密切相关， 高表达可能是膀胱癌患者的不良生物标志物。
