Enhanced Expression of Predicts Poor Prognosis in Bladder Cancer Based on the GSE13507.

Bladder cancer is one of the most common urogenital malignancies in the world, and there are no adequate prognostic indicators. is one of the atypical cyclins, which may be related to the cell cycle and even the development of cancers. Early studies have shown that is closely related to the occurrence and development of many malignant tumors. However, the mechanism of in bladder cancer has not been reported. In our research, we explored the different expressions of between 411 bladder cancers and 19 normal bladder tissues based on the TCGA dataset. -related signaling pathways were identified through the GSEA. We analyzed the associations of expression and bladder cancer progression and survival using GSE13507. Compared with 19 cases of normal bladder tissue, gene expression was increased in 411 cases of bladder cancer. The high expression of strongly correlated with grade ( < 0.0001), T classification ( = 0.0001), N classification ( = 0.00011), M classification ( = 0.044), age ( = 0.027), and gender ( = 0.0012). Bladder cancer patients with high expression had shorter overall survival ( < 0.001). In the meantime, univariate and multivariate analyses showed that the increased expression of was an independent factor for poor prognosis in bladder cancer patients ( < 0.001 and < 0.001, respectively). expression is closely related to bladder cancer progression, and the high expression of may be an adverse biomarker in bladder cancer patients.