Dreizzen E, Migdal M, Praud J P, Magny J F, Dehan M, Chambille B, Gaultier C
Neonatal Department, Hospital Antoine Béclère, Clamart, France.
J Pediatr. 1988 May;112(5):778-81. doi: 10.1016/s0022-3476(88)80702-9.
The passive compliance of the total respiratory system (CRS) was measured by the occlusion technique in 34 preterm newborn infants with respiratory distress syndrome. Gestational age ranged from 27 to 33 weeks. Preterm newborn infants were divided into four groups on the basis of clinical criteria. Group 1 consisted of 10 infants tested during the first postnatal days (1 to 3 days) while acutely ill and requiring ventilation and oxygen therapy. After the acute phase of respiratory distress syndrome, two groups were tested: group 2 consisted of nine infants (5 to 22 days of age) who no longer required ventilation, and group 3 consisted of six infants (7 to 28 days of age) who subsequently had bronchopulmonary dysplasia. Group 4 consisted of nine infants older than 1 month of age with confirmed bronchopulmonary dysplasia. Group 1 had significantly lower CRS and CRS normalized for body weight (CRS/BW) than group 2 had (P less than 0.001). In groups 3 and 4 CRS was significantly lower than in group 2 (P less than 0.001), as was CRS/BW (P less than 0.001). There was no significant difference in CRS and CRS/BW values between groups 3 and 4. This cross-sectional study in preterm infants with respiratory distress syndrome suggests that CRS may have predictive value in regard to development of bronchopulmonary dysplasia after the acute phase of respiratory distress syndrome.
采用阻断技术对34例患有呼吸窘迫综合征的早产新生儿的全呼吸系统被动顺应性（CRS）进行了测量。胎龄为27至33周。早产新生儿根据临床标准分为四组。第1组由10例在出生后最初几天（1至3天）急性患病且需要通气和氧疗时接受测试的婴儿组成。在呼吸窘迫综合征急性期过后，对两组进行了测试：第2组由9例（5至22日龄）不再需要通气的婴儿组成，第3组由6例（7至28日龄）随后发生支气管肺发育不良的婴儿组成。第4组由9例年龄超过1个月且确诊为支气管肺发育不良的婴儿组成。第1组的CRS以及经体重校正的CRS（CRS/BW）显著低于第2组（P<0.001）。第3组和第4组的CRS显著低于第2组（P<0.001），CRS/BW也是如此（P<0.001）。第3组和第4组之间的CRS和CRS/BW值没有显著差异。这项针对患有呼吸窘迫综合征的早产婴儿的横断面研究表明，CRS可能对呼吸窘迫综合征急性期过后支气管肺发育不良的发生具有预测价值。
