俄罗斯符拉迪沃斯托克市出血热伴肾综合征。

Hemorrhagic Fever With Renal Syndrome in Vladivostok City, Russia.

机构信息

Department of Genomic Research, State Research Center of Virology and Biotechnology "Vector", Koltsovo, Russia.

Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States.

出版信息

Front Public Health. 2021 Feb 5;9:620279. doi: 10.3389/fpubh.2021.620279. eCollection 2021.

DOI:10.3389/fpubh.2021.620279

PMID:33614585

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7892620/

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is a public health problem in Vladivostok city, Russia. From 1997 to 2019, a study of hantaviruses in Norway rats (), a natural reservoir of Seoul virus (SEOV), and in HFRS patients was conducted. We demonstrated the presence of SEOV in the local population of Norway rats and detected SEOV in 10, Amur virus (AMRV) in 4 and Hantaan virus (HTNV) in 1 out of 15 HFRS patients. Genetic analysis based on partial S, M and L segment sequences revealed that the Russian SEOV strains were related most closely to strains from Cambodia and Vietnam. We postulate that the SEOV strains found in the port city of Vladivostok have been spread from South-East Asia as a result of distribution of rats during standard shipping trade activities. Moreover, we suggest that city residents may have acquired AMRV and HTNV infection during visits to rural areas.

摘要

肾综合征出血热（HFRS）是俄罗斯符拉迪沃斯托克市的一个公共卫生问题。从 1997 年到 2019 年，对当地的褐家鼠（HFRS 的天然宿主）和 HFRS 患者中的汉坦病毒进行了研究。我们证明了当地褐家鼠种群中 SEOV 的存在，并在 15 例 HFRS 患者中检测到 10 例 SEOV、4 例 AMRV 和 1 例 HTNV。基于部分 S、M 和 L 片段序列的遗传分析表明，俄罗斯 SEOV 株与柬埔寨和越南的株系最为密切相关。我们推测，在港口城市符拉迪沃斯托克发现的 SEOV 株是由于标准航运贸易活动中老鼠的分布而从东南亚传播而来的。此外，我们认为城市居民在前往农村地区时可能感染了 AMRV 和 HTNV。