2000-2022 年俄罗斯肾综合征出血热病例。
Cases of Hemorrhagic Fever with Renal Syndrome in Russia during 2000-2022.
机构信息
FSASI "Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences" (Institute of Poliomyelitis), 108819 Moscow, Russia.
Department of Internal Disease Propaedeutics, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
出版信息
Viruses. 2023 Jul 12;15(7):1537. doi: 10.3390/v15071537.
During 2000-2022, a total of 69 of Russia's 85 administrative regions reported 164,580 hemorrhagic fever with renal syndrome (HFRS) cases, with an annual average rate of 4.9 cases/100,000 population (10 popul.). European Russia reported 162,045 (98.5%) cases in 53/60 regions with 9.7 cases/10 popul. Asian Russia reported 2535 (1.5%) cases in 16/25 regions with 0.6 cases/10 popul. In the same period, Russia reported 668 (0.4%) fatal HFRS cases, and 4030 (2.4%) cases among children under the age of 14 years. Most HFRS cases occurred during autumn and winter. The incidence among rural residents was 6.7 per 10 popul., higher than the urban 4.4 per 10 popul.; however, among HFRS patients, rural and urban residents account for 35% and 65%, respectively. Six hantaviruses, causing HFRS of different clinical severity, were recognized as pathogens: Hantaan (HTNV) and Amur (AMUV) of species, Seoul (SEOV) of species, Puumala (PUUV) of species, and Kurkino (KURV) and Sochi (SOCV) of species, with the principal hosts , , , , , and , respectively. It was found that 97.7% of HFRS cases are caused by PUUV, therefore, this virus plays the main role in the HFRS morbidity structure in Russia.
2000 年至 2022 年期间，俄罗斯 85 个行政地区中有 69 个地区报告了 164580 例肾综合征出血热（HFRS）病例，年平均发病率为每 10 万人 4.9 例（10 人）。欧洲地区在 60 个地区中的 53 个地区报告了 162045 例（98.5%）病例，发病率为每 10 万人 9.7 例；亚洲地区在 25 个地区中的 16 个地区报告了 2535 例（1.5%）病例，发病率为每 10 万人 0.6 例。同期，俄罗斯报告了 668 例（0.4%）HFRS 死亡病例，其中 4030 例（2.4%）为 14 岁以下儿童。大多数 HFRS 病例发生在秋季和冬季。农村居民发病率为每 10 万人 6.7 例，高于城市的每 10 万人 4.4 例；然而，在 HFRS 患者中，农村和城市居民分别占 35%和 65%。六种汉坦病毒被认为是引起不同临床严重程度 HFRS 的病原体：汉坦病毒（HTNV）和阿穆尔病毒（AMUV）属于 种，汉城病毒（SEOV）属于 种，普马拉病毒（PUUV）属于 种，以及库尔诺病毒（KURV）和索契病毒（SOCV）属于 种，主要宿主分别为 、 、 、 、 和 。研究发现，97.7%的 HFRS 病例由 PUUV 引起，因此，该病毒在俄罗斯 HFRS 发病率结构中起主要作用。
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