Huang Chunyu, Ding Shuaijie, Jiang Wei, Wang Fu-Bing
Department of Molecular Pathology, Application Center for Precision Medicine, the Second Affiliated Hospital of Zhengzhou University, Academy of Medical Sciences, Henan 450052, China and Department of Electronic Science and Technology, School of Physics and Technology, Wuhan University, Wuhan 430072, China.
College of Life Science and Technology, Xinjiang University, Urumqi 830046, Xinjiang, China.
Nanoscale. 2021 Mar 4;13(8):4512-4518. doi: 10.1039/d0nr08440a.
In combating cancer, ultrasound (US)-triggered sonodynamic therapy (SDT) manifests a wide range of promising applications as a noninvasive treatment modality, thus showing potential to overcome the shortcomings and disadvantages of conventional photodynamic therapy (PDT). Reactive oxygen species (ROS)-based therapy is practically destroyed by the high concentration of glutathione (GSH) inside tumors, and depleting GSH to improve the outcome of SDT is indeed a great challenge. Herein, we designed GSH-depleting nanoplatelets for enhanced sonodynamic cancer therapy. A platelet membrane coated nanosystem (PSCI) has been designed and tested comprising mesoporous silica nanoparticles (MSNs) which have been loaded with cinnamaldehyde (CA) as an oxidative stress amplifier. The inner layer comprises the sonosensitizer IR780 and the oxidative stress amplifier CA, whereas the platelet membranes (PM) were designed and utilized as an outer layer that can target tumors, thereby enhancing the effectiveness of SDT by attenuating the capability of tumor cells for scavenging ROS with GSH. SDT and cinnamaldehyde amplify oxidative stress by acting synergistically, leading to the preferential destruction of cancer cells in vitro and in vivo. It is hoped that next-generation tumor SDT treatments will find their way with the help of this strategy.
在对抗癌症方面，超声（US）触发的声动力疗法（SDT）作为一种非侵入性治疗方式展现出广泛的应用前景，因此显示出克服传统光动力疗法（PDT）缺点和不足的潜力。基于活性氧（ROS）的疗法实际上会被肿瘤内部高浓度的谷胱甘肽（GSH）破坏，而耗尽GSH以改善SDT的效果确实是一项巨大挑战。在此，我们设计了用于增强声动力癌症治疗的耗尽GSH的纳米片。我们设计并测试了一种血小板膜包覆的纳米系统（PSCI），其由负载有肉桂醛（CA）作为氧化应激放大器的介孔二氧化硅纳米颗粒（MSN）组成。内层包含声敏剂IR780和氧化应激放大器CA，而血小板膜（PM）被设计并用作可靶向肿瘤的外层，从而通过减弱肿瘤细胞用GSH清除ROS的能力来增强SDT的效果。SDT和肉桂醛通过协同作用放大氧化应激，导致癌细胞在体外和体内被优先破坏。希望借助这一策略，下一代肿瘤SDT治疗能够找到出路。
