Tra Nguyen Thanh, Van Tuyen Nguyen, Thi Thu Ha Nguyen, Cham Ba Thi, Tu Anh Le Thi, Thuy Linh Nguyen Thi, Son Ninh The
Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Caugiay, Vietnam.
Graduate University of Science and Technology, VAST, Caugiay, Vietnam.
Nat Prod Res. 2024 May 21:1-7. doi: 10.1080/14786419.2024.2356652.
Phytochemical study of the leaves of Guillaumin resulted in the isolation of a new natural product egonol-3''-sulphate (), and two new derivatives egonol-3-methylD-galactopyranoside () and 7-methoxy-2-(3',4'-methylenedioxyphenyl)-benzofuran-5-carboxamide (). Their chemical structures were -elucidated by spectroscopic data. Compounds and significantly established a great role for the chemotaxonomic aspect. Compound showed cytotoxicity against four cancer cell lines KB, HepG2, Lu, and MCF7 with the IC values of 84.90-101.69 µg/mL, and exhibited acetylcholinesterase (AChE) inhibitory activity with the IC value of 97.08 µg/mL.
对圭亚那草叶进行植物化学研究，从中分离出一种新的天然产物丁香酚-3''-硫酸盐（），以及两种新的衍生物丁香酚-3-甲基-D-吡喃半乳糖苷（）和7-甲氧基-2-（3'，4'-亚甲二氧基苯基）-苯并呋喃-5-甲酰胺（）。通过光谱数据阐明了它们的化学结构。化合物和在化学分类学方面发挥了重要作用。化合物对四种癌细胞系KB、HepG2、Lu和MCF7显示出细胞毒性，IC值为84.90 - 101.69μg/mL，并表现出乙酰胆碱酯酶（AChE）抑制活性，IC值为97.08μg/mL。
