Shatla Mokhtar M, Faisal Ahmed S, El-Readi Mahmoud Z
Clin Lab. 2021 Feb 1;67(2). doi: 10.7754/Clin.Lab.2020.200118.
Host factors related to failure of eradication of Helicobacter pylori (H. pylori) are increasingly studied. This work aimed to study the influence of 25-hydroxy-vitamin D [25(OH)-vitD] status on the rate of H. pylori eradication.
One hundred and fifty patients infected with H. pylori were tested for serum 25(OH)-vitD level prior to 14 days clarithromycin-based triple eradication therapy. Accordingly, patients were divided into: group I (eradication successful) and group II (eradication failure). Both groups were compared regarding mean level of serum 25(OH)-vitD and number and percentage of patients with deficient 25 (OH)-vitD.
Overall rate of eradication was 72%. Mean serum level of 25(OH)-vitD was higher in the eradication successful group compared to the group of eradication failure (28.12 ± 8.10 vs. 13.54 ± 6.37; p < 0.001). The percentage of patients with 25(OH)-vitD deficiency was higher in the group of eradication failure compared to the group of successful eradication [30 (71.5%) vs. 19 (17.5%); p < 0.001]. Patients with sufficient 25(OH)-vitD had a higher rate of eradication compared to patients with deficient 25(OH)-vitD (88% vs. 38.5%).
This study suggested that deficiency of 25(OH)-vitD could be a risk factor for H. pylori eradication failure, and it recommends to investigate the effect of vitamin D supplementation on H. pylori eradication.
与幽门螺杆菌（H. pylori）根除失败相关的宿主因素受到越来越多的研究。本研究旨在探讨25-羟基维生素D [25(OH)-vitD] 水平对幽门螺杆菌根除率的影响。
150例幽门螺杆菌感染患者在接受基于克拉霉素的14天三联根除治疗前检测血清25(OH)-vitD水平。据此，患者被分为：I组（根除成功）和II组（根除失败）。比较两组患者血清25(OH)-vitD的平均水平以及25(OH)-vitD缺乏患者的数量和百分比。
总体根除率为72%。根除成功组的血清25(OH)-vitD平均水平高于根除失败组（28.12 ± 8.10 vs. 13.54 ± 6.37；p < 0.001）。根除失败组中25(OH)-vitD缺乏患者的百分比高于根除成功组 [30 (71.5%) vs. 19 (17.5%)；p < 0.001]。25(OH)-vitD充足的患者根除率高于25(OH)-vitD缺乏的患者（88% vs. 38.5%）。
本研究表明，25(OH)-vitD缺乏可能是幽门螺杆菌根除失败的一个危险因素，并建议研究补充维生素D对幽门螺杆菌根除的影响。
