Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institutet, Stockholm, Sweden.
Department of Public Health Sciences, Stockholm University, Stockholm, Sweden.
PLoS One. 2021 Feb 22;16(2):e0247138. doi: 10.1371/journal.pone.0247138. eCollection 2021.
This study aims to examine whether disparities in gestational age outcomes between foreign and Swedish-born mothers are contingent on the measure used to estimate gestational age and, if so, to identify which maternal factors are associated with the discrepancy. Using population register data, we studied all singleton live births in Sweden from 1992-2012 (n = 1,317,265). Multinomial logistic regression was performed to compare gestational age outcomes classified into very (<32 weeks) and late preterm (32-36 weeks), term and post-term derived from the last menstrual period (LMP) and ultrasound estimates in foreign- and Swedish-born women. Compared to Swedish-born women, foreign-born women had similar odds of very preterm birth (OR: 0.98 [95% CI: 0.98, 1.01]) and lower odds of moderately preterm birth (OR: 0.95 [95% CI: 0.92, 0.98]) based on ultrasound, while higher risks based on LMP (respectively, OR: 1.10 [95% CI: 1.07, 1.14] and 1.09 [95% CI: 1.06, 1.13]). Conclusions on disparities in gestational age-related outcomes by mother's country of origin depend on the method used to estimate gestational age. Except for very preterm, foreign-born women had a health advantage when gestational age is based on ultrasound, but a health disadvantage when based on LMP. Studies assessing disparities in very preterm birth by migration status are not affected by the estimation method but caution should be taken when interpreting disparities in moderately preterm and preterm birth rates.
本研究旨在探讨在估计胎龄的方法不同的情况下,外国出生和瑞典出生母亲的胎龄结局差异是否存在差异,如果存在,那么哪些产妇因素与这种差异相关。我们使用人口登记数据,研究了 1992 年至 2012 年期间在瑞典的所有单胎活产儿(n=1,317,265)。采用多变量逻辑回归比较了根据末次月经(LMP)和超声估计值分类的胎龄结局,分为非常早产(<32 周)和晚期早产(32-36 周)、足月和晚期早产,分别在外国出生和瑞典出生的女性中进行比较。与瑞典出生的女性相比,根据超声检查,外国出生的女性发生非常早产的可能性相似(OR:0.98 [95% CI:0.98,1.01]),中度早产的可能性较低(OR:0.95 [95% CI:0.92,0.98]),而根据 LMP 则风险较高(分别为 OR:1.10 [95% CI:1.07,1.14] 和 1.09 [95% CI:1.06,1.13])。关于母亲原籍国的胎龄相关结局差异的结论取决于用于估计胎龄的方法。除非常早产外,当基于超声检查时,外国出生的女性在胎龄方面具有健康优势,但当基于 LMP 时则处于健康劣势。评估移民状况与非常早产之间差异的研究不受估计方法的影响,但在解释中度早产和早产率差异时应谨慎。