Department of Pediatric Endocrinology and Diabetes, Marmara University School of Medicine, Istanbul, Turkey.
Best Pract Res Clin Endocrinol Metab. 2021 Sep;35(5):101495. doi: 10.1016/j.beem.2021.101495. Epub 2021 Feb 13.
Endocrine-disrupting chemicals (EDCs) are defined as chemicals that interfere with the function of the endocrine system. EDCs exert their hormonal effects through several mechanisms; modulating hormone receptors or changing metabolism of different hormones. EDCs also influence multiple signalling pathways while effecting the hormonal systems and possess complex dose-response curves. EDCs can exert deleterious effects on bone tissue through changing bone modelling and remodelling via altering bone paracrine hormone synthesis, the release of systemic hormones, cytokines, chemokines and growth factors, and effecting stem cell fate, as well as bone marrow mesenchymal stem cell differentiation. Evidence is accumulating of the bone disrupting effect of different groups of EDCs, such as; the perfluoroalkyl substances, the phthalate esters, the bisphenol A, the organotin compounds, the alkylphenols and the dioxin and dioxin-like compounds. This review highlights the recent discoveries of the effects of commonly found environmental chemicals on bone from basic molecular findings to clinical implications.
内分泌干扰化学物质（EDCs）被定义为干扰内分泌系统功能的化学物质。EDCs 通过几种机制发挥其激素作用；调节激素受体或改变不同激素的代谢。EDCs 还影响多种信号通路，同时影响激素系统，并具有复杂的剂量反应曲线。EDCs 可以通过改变骨旁激素合成、全身性激素释放、细胞因子、趋化因子和生长因子的释放以及影响干细胞命运和骨髓间充质干细胞分化来改变骨建模和重塑，从而对骨组织产生有害影响。越来越多的证据表明，不同组别的 EDCs 具有破坏骨的作用，如全氟烷基物质、邻苯二甲酸酯、双酚 A、有机锡化合物、烷基酚和二恶英及类似二恶英化合物。这篇综述强调了从基础分子发现到临床意义，常见环境化学物质对骨骼影响的最新发现。
