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Therapeutic potential of C1632 by inhibition of SARS-CoV-2 replication and viral-induced inflammation through upregulating let-7.

作者信息

Xie Chen, Chen Yanlian, Luo Dongling, Zhuang Zhen, Jin Heping, Zhou Haoxian, Li Xiaocui, Lin Haijun, Zheng Xiaohui, Zhang Jing, Wang Peihui, Zhao Jincun, Zhao Yong, Huang Hui

机构信息

Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.

Cardiovascular Department, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.

出版信息

Signal Transduct Target Ther. 2021 Feb 22;6(1):84. doi: 10.1038/s41392-021-00497-4.

DOI:10.1038/s41392-021-00497-4
PMID:33619243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7897876/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b6/7900102/84ecc41a5be5/41392_2021_497_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b6/7900102/84ecc41a5be5/41392_2021_497_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b6/7900102/84ecc41a5be5/41392_2021_497_Fig1_HTML.jpg

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Nat Rev Immunol. 2020 Jun;20(6):355-362. doi: 10.1038/s41577-020-0331-4. Epub 2020 May 6.
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LIN28//PD-L1 Pathway as a Target for Cancer Immunotherapy.LIN28/PD-L1 通路作为癌症免疫治疗的靶点。
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A Small-Molecule Inhibitor of Lin28.一种Lin28的小分子抑制剂。
宿主通过非编码 RNA 水平抵抗猪繁殖与呼吸综合征病毒感染。
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MSC-extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation.MSC 细胞外囊泡 microRNAs 靶向 COVID-19 中的宿主细胞进入受体：体内验证的计算建模。
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Role of microRNAs in host defense against porcine reproductive and respiratory syndrome virus infection: a hidden front line.miRNAs 在宿主防御猪繁殖与呼吸综合征病毒感染中的作用：隐藏的前线。
Front Immunol. 2024 Mar 25;15:1376958. doi: 10.3389/fimmu.2024.1376958. eCollection 2024.
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