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Opportunities and challenges with microphysiological systems: a pharma end-user perspective.

作者信息

Ewart Lorna, Roth Adrian

出版信息

Nat Rev Drug Discov. 2021 May;20(5):327-328. doi: 10.1038/d41573-020-00030-2.

DOI:10.1038/d41573-020-00030-2
PMID:33619385
Abstract
摘要

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Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.从研发到推广的组织芯片之旅:制药行业视角
An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery.
一种用于药物发现的耦合血管网络和排泄系统的十八器官微生理系统。
Microsyst Nanoeng. 2025 May 14;11(1):89. doi: 10.1038/s41378-025-00933-3.
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Molecular probes for in vivo optical imaging of immune cells.用于免疫细胞体内光学成像的分子探针。
Nat Biomed Eng. 2025 May;9(5):618-637. doi: 10.1038/s41551-024-01275-7. Epub 2025 Feb 21.
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Comparative analysis of the physiological and transport functions of various sources of renal proximal tubule cells under static and fluidic conditions in PhysioMimix T12 platform.在PhysioMimix T12平台上,对静态和流体条件下各种来源的肾近端小管细胞的生理和转运功能进行比较分析。
Drug Metab Dispos. 2025 Jan;53(1):100001. doi: 10.1124/dmd.124.001488. Epub 2024 Nov 22.
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Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure.供体衍生工程微血管用于肾衰竭患者的心血管风险分层。
Small. 2024 Jun;20(24):e2307901. doi: 10.1002/smll.202307901. Epub 2024 Jan 7.
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Towards in vitro models for reducing or replacing the use of animals in drug testing.致力于开发体外模型以减少或替代药物测试中动物的使用。
Nat Biomed Eng. 2024 Aug;8(8):930-935. doi: 10.1038/s41551-023-01154-7.
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Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems.迈向人类特异性非动物方法学的飞跃:协调全球微生理系统政策的必要性。
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Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling.基于患者来源的内皮细胞的血管类器官芯片:用于转化药物发现和疾病建模的技术。
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