Reynaud Kendra, Atwell Scott, Védrine Christophe, Guyard Cyril, Beloeil Laurent
BIOASTER Technology Research Institute, Lyon, France.
Hum Vaccin Immunother. 2025 Dec;21(1):2518641. doi: 10.1080/21645515.2025.2518641. Epub 2025 Jun 17.
Micro Physiological systems (MPS) are biomimetic platforms that reconstitute the complex architecture of human organs and tissues . MPSs have the capacity to improve clinical development pipelines as they address certain translational limitations that exist in other pre-clinical models by providing human-relevant microenvironments. These platforms have already demonstrated their potential in vaccine development, as several variations of MPSs have recently been published that provided results relevant to vaccine trials in humans. Previous MPSs include approximations of peripheral and lymphoid tissue in static platforms to study the innate and adaptive response to vaccination, as well as a lymphoid-follicle-on-chip under dynamic flow which produces antigen-specific antibodies to vaccination. Up-and-coming devices could be used to study the interplay between vaccine reactogenicity and innate immune stimulation, and thereby derisk vaccine targets by elucidating their inflammatory profiles prior to advancement to clinical trials.
微生理系统（MPS）是仿生平台，可重建人体器官和组织的复杂结构。MPS有能力改善临床开发流程，因为它们通过提供与人类相关的微环境，解决了其他临床前模型中存在的某些转化限制。这些平台已经在疫苗开发中展示了它们的潜力，因为最近已经发表了几种MPS变体，其提供了与人类疫苗试验相关的结果。以前的MPS包括在静态平台中对外周组织和淋巴组织的近似，以研究对疫苗接种的先天和适应性反应，以及在动态流动下的芯片上淋巴滤泡，其产生针对疫苗接种的抗原特异性抗体。即将出现的设备可用于研究疫苗反应原性和先天免疫刺激之间的相互作用，从而通过在推进到临床试验之前阐明其炎症特征来降低疫苗靶点的风险。
