Tan Fei, Fang Yin, Zhu Liwei, Al-Rubeai Mohamed
Department of ORL-HNS, Affiliated East Hospital of Tongji University, Shanghai, China.
School of Medicine and Institute for Advanced Study, Tongji University, Shanghai, China.
Crit Rev Biotechnol. 2021 May;41(3):425-440. doi: 10.1080/07388551.2020.1853671. Epub 2021 Feb 23.
Cold atmospheric plasma (CAP) has been intensively researched for direct treatment of living cells and tissues. Significant attention is now being given to its indirect applications in plasma medicine. Surgical implant is an exemplary conveyor to deliver the therapeutic effects of plasma to patients. There is a constant drive to enhance the clinical performance of surgical implants, targeting at the implant-tissue interface. As a versatile and potent tool, CAP is capable of ameliorating surgical implants using various strategies of interface biotechnology, such as surface modification, coating deposition, and drug delivery. Understanding the chemical, physical, mechanical, electrical, and pharmacological processes occurring at the implant-tissue interface is crucial to effective application of CAP as an interface biotechnology. This preclinical review focuses on the recent advances in CAP-assisted implant-based therapy for major surgical specialties. The ultimate goal here is to elicit unique opportunities and challenges for translating implant science to plasma medicine.
冷大气等离子体（CAP）已被深入研究用于直接处理活细胞和组织。目前，人们对其在等离子体医学中的间接应用给予了极大关注。外科植入物是将等离子体的治疗效果传递给患者的典型载体。不断有人致力于提高外科植入物的临床性能，目标是植入物与组织的界面。作为一种多功能且强大的工具，CAP能够通过各种界面生物技术策略改善外科植入物，如表面改性、涂层沉积和药物递送。了解在植入物与组织界面发生的化学、物理、机械、电学和药理学过程对于有效应用CAP作为界面生物技术至关重要。这篇临床前综述聚焦于CAP辅助的基于植入物的主要外科专科治疗的最新进展。这里的最终目标是为将植入物科学转化为等离子体医学引出独特的机遇和挑战。
