Li Xuran, Rui Xiaoqing, Li Danni, Wang Yanhong, Tan Fei
Shanghai Fourth People's Hospital, and School of Medicine, Tongji University, Shanghai, China.
Shanghai East Hospital, Shanghai, China.
Front Oncol. 2022 Sep 29;12:994172. doi: 10.3389/fonc.2022.994172. eCollection 2022.
The worldwide incidence of head and neck cancer (HNC) exceeds half a million cases annually, and up to half of the patients with HNC present with advanced disease. Surgical resection remains the mainstay of treatment for many HNCs, although radiation therapy, chemotherapy, targeted therapy, and immunotherapy might contribute to individual patient's treatment plan. Irrespective of which modality is chosen, disease prognosis remains suboptimal, especially for higher staging tumors. Cold atmospheric plasma (CAP) has recently demonstrated a substantial anti-tumor effect. After a thorough literature search, we provide a comprehensive review depicting the oncological potential of CAP in HNC treatment. We discovered that CAP applies to almost all categories of HNC, including upper aerodigestive tract cancers, head and neck glandular cancers and skin cancers. In addition, CAP is truly versatile, as it can be applied not only directly for superficial or luminal tumors but also indirectly for deep solid organ tumors. Most importantly, CAP can work collaboratively with existing clinical oncotherapies with synergistic effect. After our attempts to elaborate the conceivable molecular mechanism of CAP's anti-neoplastic effect for HNC, we provide a brief synopsis of recent clinical and preclinical trials emphasizing CAP's applicability in head and neck oncology. In conclusion, we have enunciated our vision of plasma oncology using CAP for near future HNC treatment.
全球范围内，头颈癌（HNC）的年发病率超过50万例，高达一半的头颈癌患者就诊时已处于晚期。手术切除仍然是许多头颈癌治疗的主要手段，尽管放射治疗、化疗、靶向治疗和免疫治疗可能会纳入个体患者的治疗方案。无论选择哪种治疗方式，疾病预后仍然不尽人意，尤其是对于高分期肿瘤。冷大气等离子体（CAP）最近已显示出显著的抗肿瘤作用。在进行全面的文献检索后，我们提供了一篇综述，描述了CAP在头颈癌治疗中的肿瘤学潜力。我们发现，CAP适用于几乎所有类型的头颈癌，包括上呼吸道消化道癌、头颈腺癌和皮肤癌。此外，CAP具有真正的通用性，因为它不仅可以直接应用于浅表或腔内肿瘤，还可以间接应用于深部实体器官肿瘤。最重要的是，CAP可以与现有的临床肿瘤治疗方法协同发挥作用。在我们试图阐述CAP对头颈癌抗肿瘤作用可能的分子机制后，我们简要概述了最近的临床和临床前试验，强调了CAP在头颈肿瘤学中的适用性。总之，我们阐述了在不久的将来使用CAP进行头颈癌治疗的等离子体肿瘤学愿景。
