Zhu Grace G, Witt Benjamin L, Winter Iii Thomas C, Rogers Douglas M
Department of Radiology, University of Utah Health, Salt Lake City, UT, USA.
Department of Anatomical Pathology, University of Utah Health, Salt Lake City, UT, USA.
BMJ Case Rep. 2021 Feb 23;14(2):e239107. doi: 10.1136/bcr-2020-239107.
Myelolipomas are benign tumours typically occurring in the adrenal glands, made up of fat and trilineage haematopoeitic cells resembling bone marrow. Their aetiology is not well understood; however, they have a clear association with elevated serum adrenocorticotropic hormone (ACTH). Extra-adrenal myelolipomas are rare, and to our knowledge there are no previously reported cases of multiple enlarging hepatic and retroperitoneal myelolipomas in the setting of Cushing disease. We present the case of a patient with an ACTH-producing pituitary adenoma who developed multiple enlarging fat containing lesions in the liver and retroperitoneum, which were histologically proven multifocal myelolipomas.
髓脂肪瘤是一种通常发生于肾上腺的良性肿瘤，由脂肪和类似于骨髓的三系造血细胞组成。其病因尚不明确；然而，它们与血清促肾上腺皮质激素（ACTH）升高有明确关联。肾上腺外髓脂肪瘤较为罕见，据我们所知，此前尚无在库欣病背景下出现多发增大的肝脏和腹膜后髓脂肪瘤的病例报道。我们报告一例患有分泌ACTH的垂体腺瘤患者，该患者在肝脏和腹膜后出现多发增大的含脂肪病变，经组织学证实为多灶性髓脂肪瘤。
