完全切除结直肠癌肺转移患者免疫指标的预后意义。
Prognostic Significance of the Immunological Indices in Patients Who Underwent Complete Resection of Pulmonary Metastases of Colorectal Cancer.
机构信息
Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan;
出版信息
In Vivo. 2021 Mar-Apr;35(2):1091-1100. doi: 10.21873/invivo.12354.
Abstract
BACKGROUND/AIM: The neutrophil-to-lymphocyte ratio (NLR) and the density of tumor-infiltrating lymphocytes (TILs) have been reported as immunological prognostic factors for various cancers. We evaluated the association between the prognosis and the immunological status in patients who underwent complete resection of pulmonary metastases of colorectal cancer (CRC).
PATIENTS AND METHODS
We evaluated the associations between the NLR before the resection of pulmonary metastases and the relapse-free survival (RFS) or overall survival (OS), or between the density of TILs in the pulmonary metastasis and the RFS or OS.
RESULTS
The RFS and OS were significantly worse in the NLR-High group than in the NLR-Low group. The RFS was significantly longer in the CD3TILs-High group than in the CD3TILs-Low group.
CONCLUSION
The NLR and the density of TILs may have prognostic significance in patients who undergo complete resection of pulmonary metastases of CRC.
摘要
背景/目的：中性粒细胞与淋巴细胞比值（NLR）和肿瘤浸润淋巴细胞（TILs）密度已被报道为各种癌症的免疫预后因素。我们评估了在接受结直肠癌（CRC）肺转移完全切除的患者中，预后与免疫状态之间的相关性。
患者和方法
我们评估了肺转移切除前 NLR 与无复发生存期（RFS）或总生存期（OS）之间的关系，或 TILs 密度与 RFS 或 OS 之间的关系。
结果
NLR 高组的 RFS 和 OS 明显差于 NLR 低组。CD3TILs 高组的 RFS 明显长于 CD3TILs 低组。
结论
在接受结直肠癌肺转移完全切除的患者中，NLR 和 TILs 密度可能具有预后意义。
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