Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan;
Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
In Vivo. 2021 Mar-Apr;35(2):1261-1269. doi: 10.21873/invivo.12377.
BACKGROUND/AIM: The prognosis of colorectal cancer is reported to differ depending on the tumor site, and clinical differences depending on the site of occurrence have gained attention. The aim was to compare nutrition index and inflammatory markers according to the site of colon cancer.
We retrospectively analyzed 272 cases of stage I-III colon cancer (55% males, 45% females). The clinical characteristics, nutrition index and inflammatory markers were compared between patients with right colon cancer (RCC, n=119) and those with left colon cancer (LCC, n=153), and the relapse-free survival was then compared.
RCC was associated with older age (p=0.03), female gender (p=0.003), higher T stage (p=0.01), elevated platelet/lymphocyte ratio (PLR) (p=0.009), and elevated CONUT score (p=0.028). The prognostic values differed between RCC and LCC (RCC: CONUT score, p=0.04, LCC: PLR, p=0.02).
RCC was associated with an elevated CONUT score and PLR. In RCC, the CONUT score was an independent recurrence factor, and in LCC, the PLR was an independent recurrence factor.
背景/目的：据报道，结直肠癌的预后因肿瘤部位而异，且发生部位的临床差异已引起关注。本研究旨在比较结肠癌不同部位的营养指标和炎症标志物。
我们回顾性分析了 272 例 I-III 期结肠癌患者（男性占 55%，女性占 45%）。比较了右半结肠癌（RCC，n=119）和左半结肠癌（LCC，n=153）患者的临床特征、营养指标和炎症标志物，并比较了无复发生存率。
RCC 与年龄较大（p=0.03）、女性（p=0.003）、较高 T 分期（p=0.01）、较高血小板/淋巴细胞比值（PLR）（p=0.009）和较高 CONUT 评分（p=0.028）相关。RCC 和 LCC 之间的预后价值存在差异（RCC：CONUT 评分，p=0.04，LCC：PLR，p=0.02）。
RCC 与较高的 CONUT 评分和 PLR 相关。在 RCC 中，CONUT 评分是独立的复发因素，而在 LCC 中，PLR 是独立的复发因素。
