Precancerous Gastric Lesions with /2/ Genotype Increase the Risk of Gastric Cancer.

OBJECTIVE

The clinical outcomes of gastric diseases such as chronic gastritis, peptic ulcer, and gastric cancer have been attributed to the interplay of virulence factors of (), host genetic susceptibility, and host immune responses. This study investigated the presence of , , 2, 2, and genes and their association with clinical outcomes.

METHODS

Chronic gastritis, atrophic gastritis, and intestinal metaplasia specimens were obtained from patients who underwent endoscopy and surgical resection between January 2017 and December 2018; specimens from gastric cancer patients treated between January 2014 and December 2018 were also added. ), host genetic susceptibility, and host immune responses. This study investigated the presence of , , 2, 2, and genes and their association with clinical outcomes. ), host genetic susceptibility, and host immune responses. This study investigated the presence of.

RESULTS

), host genetic susceptibility, and host immune responses. This study investigated the presence of , 2, and genes and their association with clinical outcomes. , 2, and genes and their association with clinical outcomes. =0.033, OR = 2.64; 95% CI = 1.44-4.82, =0.033, OR = 2.64; 95% CI = 1.44-4.82, =0.033, OR = 2.64; 95% CI = 1.44-4.82, /2, and genes and their association with clinical outcomes. =0.033, OR = 2.64; 95% CI = 1.44-4.82.

CONCLUSION

In this present study, we reported on the virulence genes of infection to reveal their association with increased risk of chronic gastritis, precancerous gastric lesions, and gastric cancer. Precancerous gastric lesions with +/2+/+ genotype increased the risk of gastric cancer.), host genetic susceptibility, and host immune responses. This study investigated the presence of /2, and genes and their association with clinical outcomes.