Sutherling W W, Crandall P H, Cahan L D, Barth D S
Department of Neurology, UCLA School of Medicine 90024-1769.
Neurology. 1988 May;38(5):778-86. doi: 10.1212/wnl.38.5.778.
The magnetoencephalogram (MEG) and electroencephalogram (EEG) were measured during interictal epileptic spikes in nine patients with complex partial seizures. The MEG localization estimates were compared with localizations by intraoperative cortical electrodes, subdural electrodes, stereotaxic depth electrodes, anatomic imaging, postoperative pathologic analysis, and postoperative follow-up. In all patients, MEG localization estimates were in the same lobe as the epileptic focus determined by invasive methods and EEG. In two patients, it was possible to quantify precisely the accuracy of MEG localization by mapping a spike focus that was visually indistinguishable on MEG and cortical recordings. In both patients, MEG localization was approximately 12 mm from the center of the cortical spike focus on intracranial recordings. In eight patients, MEG showed tangential dipolar field patterns on the spontaneous record, but EEG did not. In one patient, a cortical epileptic discharge was detected only on MEG for some discharges and only on EEG for other discharges. The MEG did not detect deep spikes with present levels of environmental noise.
在9例复杂部分性发作患者的发作间期癫痫棘波期间测量了脑磁图（MEG）和脑电图（EEG）。将MEG定位估计结果与术中皮层电极、硬膜下电极、立体定向深度电极、解剖成像、术后病理分析及术后随访的定位结果进行了比较。在所有患者中，MEG定位估计结果与通过侵入性方法和EEG确定的癫痫病灶位于同一脑叶。在2例患者中，通过绘制在MEG和皮层记录上视觉上无法区分的棘波病灶，可以精确量化MEG定位的准确性。在这2例患者中，MEG定位与颅内记录上皮层棘波病灶中心的距离约为12毫米。在8例患者中，MEG在自发记录上显示出切向偶极场模式，而EEG未显示。在1例患者中，对于某些放电，仅在MEG上检测到皮层癫痫放电，而对于其他放电，仅在EEG上检测到。在当前环境噪声水平下，MEG未检测到深部棘波。
