Sutherling W W, Crandall P H, Engel J, Darcey T M, Cahan L D, Barth D S
Ann Neurol. 1987 Jun;21(6):548-58. doi: 10.1002/ana.410210605.
The magnetoencephalogram (MEG) was recorded during 63 complex partial seizures in 4 patients. The MEG showed large biomagnetic signals occurring at the same time as discharges recorded from scalp electroencephalogram (EEG). These MEG signals had the same morphology and frequency as the discharges from the EEG. The location of the seizure focus was verified by depth electrode recordings in 2 patients and by lesions shown on computed tomographic scan and magnetic resonance imaging in the other 2. In each patient, MEG localization estimates were consistent with the location of the seizure focus shown by other methods. When seizures were recorded repeatedly and mapped with a single-channel magnetometer placed at different scalp locations in a single patient, the MEG localization agreed with the electrographic seizure focus localized from depth electrodes. In the maps, the MEG resolved an ambiguity in the scalp EEG and therefore increased the confidence of localization. MEG recordings of seizures may help localize epileptic foci noninvasively.
在4例患者的63次复杂部分性发作期间记录了脑磁图（MEG）。MEG显示，在头皮脑电图（EEG）记录到放电的同时出现了大的生物磁信号。这些MEG信号与EEG放电具有相同的形态和频率。2例患者通过深部电极记录证实了癫痫发作灶的位置，另外2例通过计算机断层扫描和磁共振成像显示的病变证实。在每例患者中，MEG定位估计与其他方法显示的癫痫发作灶位置一致。当在1例患者的不同头皮位置用单通道磁力计重复记录发作并绘制图谱时，MEG定位与深部电极定位的脑电图癫痫发作灶一致。在图谱中，MEG解决了头皮EEG中的模糊性，从而提高了定位的可信度。癫痫发作的MEG记录可能有助于无创性地定位癫痫病灶。
