Department of Clinical Medicine and Surgery, Federico II University, Via S. Pansini 5, 80131 Naples, Italy.
Department of Molecular Medicine and Biotechnology, Federico II University, Via S. Pansini 5, 80131 Naples, Italy.
Eur J Prev Cardiol. 2022 Feb 9;28(18):1980-1990. doi: 10.1093/eurjpc/zwaa029.
Lower limb peripheral artery disease (PAD) is a leading cause of atherosclerotic cardiovascular disease (ASCVD). Discordant data are available on the association between apolipoprotein and PAD. We performed a meta-analyses on the association between apolipoprotein (apo)B, apoA-I, and apoB/apoA-I ratio with PAD.
PubMed, Web of Science, Scopus databases were systematically searched. Studies providing data about apoB, apoA-I, apoB/apoA-I ratio in PAD subjects and non-PAD controls were included. Differences between PAD and non-PAD subjects were expressed as mean difference (MD) with pertinent 95% confidence intervals (95%CI). Twenty-two studies were included. Peripheral artery disease subjects showed higher apoB (MD: 12.5 mg/dL, 95%CI: 2.14, 22.87) and lower apoA-I levels (MD: -7.11 mg/dL, 95%CI: -11.94, -2.28) than non-PAD controls. Accordingly, ApoB/ApoA-I ratio resulted higher in PAD subjects than non-PAD controls (MD: 0.11, 95% CI: 0.00, 0.21). Non-HDL-C showed a direct association with the difference in apoB (z-value: 4.72, P < 0.001) and an inverse association with the difference of apoA-I (z-value: -2.43, P = 0.015) between PAD subjects and non-PAD controls. An increasing BMI was associated with an increasing difference in apoA-I values between PAD subjects and non-PAD controls (z-value: 1.98, P = 0.047).
Our meta-analysis suggests that PAD subjects exhibit increased apoB and reduced apoA-I levels, accompanied by an increased apoB/apoA-I ratio as compared with non-PAD controls.
下肢外周动脉疾病（PAD）是动脉粥样硬化性心血管疾病（ASCVD）的主要原因。载脂蛋白与 PAD 之间的关联存在不一致的数据。我们对载脂蛋白（apo）B、apoA-I 和 apoB/apoA-I 比值与 PAD 之间的关联进行了荟萃分析。
系统地检索了 PubMed、Web of Science 和 Scopus 数据库。纳入了提供 PAD 患者和非 PAD 对照组中 apoB、apoA-I 和 apoB/apoA-I 比值数据的研究。PAD 和非 PAD 患者之间的差异用均值差（MD）及其相关 95%置信区间（95%CI）表示。纳入了 22 项研究。与非 PAD 对照组相比，外周动脉疾病患者的 apoB 水平更高（MD：12.5mg/dL，95%CI：2.14，22.87），而 apoA-I 水平更低（MD：-7.11mg/dL，95%CI：-11.94，-2.28）。相应地，与非 PAD 对照组相比，PAD 患者的 apoB/apoA-I 比值更高（MD：0.11，95%CI：0.00，0.21）。非高密度脂蛋白胆固醇（Non-HDL-C）与 PAD 患者与非 PAD 对照组之间 apoB 差值呈直接相关（z 值：4.72，P<0.001），与 apoA-I 差值呈负相关（z 值：-2.43，P=0.015）。BMI 的增加与 PAD 患者与非 PAD 对照组之间 apoA-I 值的差异呈正相关（z 值：1.98，P=0.047）。
我们的荟萃分析表明，与非 PAD 对照组相比，PAD 患者表现出 apoB 水平升高和 apoA-I 水平降低，同时伴有 apoB/apoA-I 比值升高。
