Gilbertson Hayley, Fang Lin, Andrzejewski Jeremy A, Carlson Joshua M
Department of Psychological Science, Northern Michigan University, Marquette, MI, USA.
Psychophysiology. 2021 May;58(5):e13794. doi: 10.1111/psyp.13794. Epub 2021 Feb 24.
The error-related negativity (ERN) is a response-locked event-related potential, occurring approximately 50 ms following an erroneous response at frontocentral electrode sites. Source localization and functional magnetic resonance imaging (fMRI) research indicate that the ERN is likely generated by activity in the dorsal anterior cingulate cortex (dACC). The dACC is thought to be a part of a broader network of brain regions that collectively comprise an error monitoring network. However, little is known about how intrinsic connectivity within the dACC-based error monitoring network contributes to variability in ERN amplitude. The purpose of this study was to assess the relationship between dACC functional connectivity and ERN amplitude. In a sample of highly trait anxious individuals, the ERN was elicited in a flanker task and functional connectivity was assessed in a 10-min resting-state fMRI scan. Results suggest that the strength of dACC seeded functional connectivity with the supplementary motor area is correlated with the ΔERN (i.e., incorrect-correct responses) amplitude such that greater ΔERN amplitude was accompanied by greater functional coupling between these regions. In sum, ERN amplitude appears to be related to the strength of functional connectivity between error monitoring and motor control regions of the brain.
错误相关负波（ERN）是一种与反应锁定的事件相关电位，在额中央电极部位出现错误反应后约50毫秒发生。源定位和功能磁共振成像（fMRI）研究表明，ERN可能由背侧前扣带回皮质（dACC）的活动产生。dACC被认为是更广泛的脑区网络的一部分，这些脑区共同构成一个错误监测网络。然而，对于基于dACC的错误监测网络内的内在连接如何导致ERN振幅的变异性，人们知之甚少。本研究的目的是评估dACC功能连接与ERN振幅之间的关系。在一个高特质焦虑个体样本中，通过侧翼任务诱发ERN，并在10分钟静息态fMRI扫描中评估功能连接。结果表明，dACC与辅助运动区之间种子功能连接的强度与ΔERN（即错误-正确反应）振幅相关，即更大的ΔERN振幅伴随着这些区域之间更强的功能耦合。总之，ERN振幅似乎与大脑错误监测和运动控制区域之间功能连接的强度有关。
