Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Philipps Universität Marburg, Marburg, Germany.
Upper Airways Research Laboratory and Department of Oto-Rhino-Laryngology, Ghent University and Ghent University Hospital, Ghent, Belgium.
Scand J Immunol. 2021 Jun;93(6):e13032. doi: 10.1111/sji.13032. Epub 2021 Mar 11.
Over the last century, eosinophils have been regarded ambiguously either as 'friends' or 'foes'. Recent developments have greatly enhanced our understanding of the role and function of eosinophils in health and disease. Pathogenic eosinophilic inflammation can lead to severe diseases in various organs, such as the gastrointestinal tract, airways, heart and skin. In a 2-day focus workshop of the German Society for Allergology and Clinical Immunology (DGAKI), the state of the art was discussed and practical recommendations for diagnosis and treatment of eosinophilic diseases, with a particular focus on new biologics, such as anti-interleukin 5 and anti-interleukin 5R, were derived.
在过去的一个世纪里，嗜酸性粒细胞一直被模糊地视为“朋友”或“敌人”。最近的发展极大地提高了我们对嗜酸性粒细胞在健康和疾病中的作用和功能的理解。致病性嗜酸性粒细胞炎症可导致胃肠道、气道、心脏和皮肤等各种器官的严重疾病。在德国变态反应学和临床免疫学学会（DGAKI）为期两天的重点研讨会上，讨论了最新进展，并就嗜酸性粒细胞疾病的诊断和治疗提出了实用建议，特别关注新型生物制剂，如抗白细胞介素 5 和抗白细胞介素 5 受体。
