Bioprospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, 226015, India.
Analytical Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, Uttar Pradesh, India.
Phytother Res. 2021 Jun;35(6):3325-3336. doi: 10.1002/ptr.7053. Epub 2021 Feb 24.
The aim of this study is to explore the possible pharmacological effects of fruit waste that may have a key role in converting the fruit waste into pharmaceutical agents. Citrus limetta (Rutaceae) is an important commercial citrus fruit crops used by juice processing industries. C. limetta peels are perishable waste material, which creates a big challenge in juice processing industries. Initial pharmaco-chemical profile of peels' extracts revealed that the ethanol extract (ClPs) has promising anti-inflammatory activity and rich in hesperidin content. In vivo experimental pharmacology profile of ClPs against arthritis and related complications revealed that oral administration of ClPs significantly reduced the arthritis score and arthritis index in elbow and knee joints against collagen-induced arthritis (CIA) in rats. Biochemical parameters include pro-inflammatory cytokines (TNF-α, IL-6, and IL-17A), and C-RP level in blood serum of CIA rats further confirmed the anti-arthritic profile of ClPs. Further individual experiments related to arthritis-related complications in experimental animals demonstrated the analgesic, anti-inflammatory, and antipyretic potential of ClPs in dose-dependent manner. The result of this study suggests the suitability of ClPs as a drug-like candidate for further investigation toward the management of arthritis and related complications.
本研究旨在探索水果废料可能具有的药理学作用，这些作用可能是将水果废料转化为药物的关键。酸橙（芸香科）是一种重要的商业柑橘类水果，被果汁加工行业使用。酸橙皮是易腐的废料，这在果汁加工行业中带来了巨大的挑战。果皮提取物的初步药物化学特征揭示，乙醇提取物（ClPs）具有有希望的抗炎活性，并且富含橙皮苷。ClPs 对关节炎及相关并发症的体内实验药理学特征表明，ClPs 的口服给药可显著降低胶原诱导性关节炎（CIA）大鼠肘和膝关节的关节炎评分和关节炎指数。血液生化参数包括促炎细胞因子（TNF-α、IL-6 和 IL-17A）和血清 C-反应蛋白水平，进一步证实了 ClPs 的抗关节炎特征。与实验动物关节炎相关并发症相关的进一步单独实验表明，ClPs 具有镇痛、抗炎和退热作用，且呈剂量依赖性。这项研究的结果表明，ClPs 适合作为候选药物进行进一步研究，以管理关节炎及相关并发症。
