Department of Veterinary Clinical Sciences, Oklahoma State University, Stillwater, Oklahoma, USA.
Department of Clinical Sciences, Kansas State University, Manhattan, Kansas, USA.
J Vet Intern Med. 2021 Mar;35(2):1164-1169. doi: 10.1111/jvim.16059. Epub 2021 Feb 24.
There are no commercially available handheld blood creatinine analyzers validated in goats.
The objective of the study was to validate the accuracy of a handheld point-of-care (POC) analyzer (Nova StatSensor) for quantifying blood creatinine concentration in goats. A secondary objective was to compare this POC against a chemistry analyzer to classify goats as normal or having mild or moderate azotemia.
Sixty-three goats admitted to a referral hospital.
Cross-sectional study. Venous blood was obtained, and creatinine concentration was measured by the POC in duplicate. Plasma was submitted for creatinine determination via the chemistry analyzer (gold standard).
A total of 101 blood samples were collected from 63 goats. There was high repeatability for creatinine concentrations obtained by the POC (adjusted R = .97, P < .0001). Correlation of POC concentrations with those reported by the chemistry analyzer was moderate (adjusted R = .57, P < .0001). When correctly categorizing goats with mild azotemia, the POC demonstrated a sensitivity of 73.3% and a specificity of 88.3%. For moderate to severe azotemia, the POC had a sensitivity of 75.0% and specificity of 97.5%.
The Nova StatSensor POC provided above average accuracy for measuring blood creatinine concentration in goats compared with the gold standard test.
目前尚无经过商业验证的适用于山羊的手持式血肌酐分析仪。
本研究旨在验证一种手持式即时（POC）分析仪（Nova StatSensor）用于定量山羊血肌酐浓度的准确性。次要目的是将该 POC 与化学分析仪进行比较，以将山羊分为正常、轻度或中度氮血症。
63 只被转诊到医院的山羊。
横断面研究。采集静脉血，通过 POC 重复测量两次肌酐浓度。将血浆提交给化学分析仪（金标准）进行肌酐测定。
从 63 只山羊中采集了 101 份血样。POC 获得的肌酐浓度具有很高的重复性（调整后的 R =.97，P < .0001）。POC 浓度与化学分析仪报告的浓度之间的相关性为中度（调整后的 R =.57，P < .0001）。当正确分类轻度氮血症的山羊时，POC 的灵敏度为 73.3%，特异性为 88.3%。对于中重度氮血症，POC 的灵敏度为 75.0%，特异性为 97.5%。
与金标准检测相比，Nova StatSensor POC 在测量山羊血肌酐浓度方面具有较高的准确度。
