Department of Ultrasound, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
Department of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
Turk J Gastroenterol. 2020 Dec;31(12):923-929. doi: 10.5152/tjg.2020.20139.
BACKGROUND/AIMS: The importance of identifying the stage of liver fibrosis has motivated the development of non-invasive methods. This study aimed to evaluate the applicability of ultrasound analysis involving the wave-number domain attenuation coefficient (W-Ac) in the non-invasive quantitative differentiation of liver fibrosis.
This was a prospective study of inpatients with hepatitis B-related liver disease treated between October 2016 and January 2018. In ultrasound, the echo from the near-field liver tissue was selected as the reference signal. The W-Ac of liver tissues was based on the fast Fourier transform of the acquired post-beamforming radio frequency signals. These values were compared with fibrosis from biopsy METAVIR score results. A receiver operating characteristic (ROC) curve tested the W-Ac method.
A total of 46 patients were enrolled, including 27 males and 19 females. Fibrosis was stage F0 in 12 patients, F1 in 13 patients, F2 in 10 patients, F3 in 7 patients, and F4 in 4 patients. W-Ac increased with the progression of liver fibrosis up to stage F3. There were differences between F0 and F4 stages (p<0.001) and between any 2 stages of fibrosis (p<0.05), except for stages F3 and F4. There was a significant correlation between W-Ac and METAVIR score (r=0.795, p<0.001). W-Ac differed between non-fibrosis (F0) and fibrosis (F1-F4) groups (p<0.001) and in the normal (F0), early fibrosis (F1-2), and late fibrosis groups (F3-4) (p<0.001). ROC area under the curve was 0.890, and at a cut-off of 0.12153, sensitivity was 0.706 and specificity was 0.830.
W-Ac allowed assessment of liver fibrosis in clinical practice.
背景/目的：识别肝纤维化分期的重要性促使人们开发了非侵入性方法。本研究旨在评估超声分析中波数域衰减系数（W-Ac）在非侵入性定量区分肝纤维化中的适用性。
这是一项 2016 年 10 月至 2018 年 1 月间收治的乙型肝炎相关肝病住院患者的前瞻性研究。在超声中，选择近场肝组织的回波作为参考信号。肝组织的 W-Ac 是基于获取的波束成形射频信号的快速傅里叶变换。这些值与活检 METAVIR 评分结果的纤维化进行比较。接收者操作特性（ROC）曲线测试了 W-Ac 方法。
共纳入 46 例患者，其中男 27 例，女 19 例。纤维化程度为 F0 期 12 例，F1 期 13 例，F2 期 10 例，F3 期 7 例，F4 期 4 例。W-Ac 随肝纤维化进展至 F3 期而增加。F0 期和 F4 期之间存在差异（p<0.001），任何两个纤维化阶段之间也存在差异（p<0.05），除了 F3 期和 F4 期。W-Ac 与 METAVIR 评分呈显著相关（r=0.795，p<0.001）。W-Ac 在非纤维化（F0）和纤维化（F1-F4）组之间存在差异（p<0.001），在正常（F0）、早期纤维化（F1-2）和晚期纤维化（F3-4）组之间也存在差异（p<0.001）。ROC 曲线下面积为 0.890，在截止值为 0.12153 时，灵敏度为 0.706，特异性为 0.830。
W-Ac 可用于评估临床实践中的肝纤维化。
