Wang Qiuyuan, Liu Yang, Wu Yiru, Wen Jie, Man Chaolai
College of Life Science and Technology, Harbin Normal University, Harbin, China.
PeerJ. 2021 Feb 16;9:e10924. doi: 10.7717/peerj.10924. eCollection 2021.
MicroRNAs are a class of evolutionary conserved non-coding small RNAs that play key regulatory roles at the post-transcriptional level. In recent years, studies have shown that miR-214 plays an important role in regulating several biological processes such as cell proliferation and differentiation, tumorigenesis, inflammation and immunity, and it has become a hotspot in the miRNA field. In this review, the regulatory functions of miR-214 in the proliferation, differentiation and functional activities of immune-related cells, such as dendritic cells, T cells and NK cells, were briefly reviewed. Also, the mechanisms of miR-214 involved in tumor immunity, inflammatory regulation and antivirus were discussed. Finally, the value and application prospects of miR-214 as a molecular marker in inflammation and tumor related diseases were analyzed briefly. We hope it can provide reference for further study on the mechanism and application of miR-214.
微小RNA是一类进化保守的非编码小RNA，在转录后水平发挥关键调节作用。近年来，研究表明miR-214在调节细胞增殖与分化、肿瘤发生、炎症和免疫等多种生物学过程中发挥重要作用，已成为微小RNA领域的研究热点。本文综述了miR-214在树突状细胞、T细胞和NK细胞等免疫相关细胞的增殖、分化及功能活动中的调节作用。此外，还讨论了miR-214参与肿瘤免疫、炎症调节和抗病毒的机制。最后，简要分析了miR-214作为炎症和肿瘤相关疾病分子标志物的价值及应用前景。希望能为进一步研究miR-214的机制及应用提供参考。
