Brar Simrandeep K, Perveen Sumera, Chaudhry Muhammad Reza, AlBabtain Sarah, Amreen Sana, Khan Safeera
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine/Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2021 Jan 20;13(1):e12804. doi: 10.7759/cureus.12804.
Anemia is a common complication of certain chronic diseases and can be treated by stimulating hematopoietic cells to increase red blood cell count, and this action is achieved by recombinant human erythropoietin. In this review article, we have discussed about hypertension, which develops as a result of erythropoietin therapy. We have explored the pathogenesis of erythropoietin-induced hypertension and discussed some ways to prevent and treat this condition. Also, an attempt has been made to find out the role of blood viscosity in erythropoietin-induced hypertension. We conducted a comprehensive review of literature by collecting data from online databases like PubMed and Google Scholar. We mainly studied clinical trials that unraveled the mechanism of hypertension caused by erythropoietin. Hypertension is mainly caused due to enhanced vascular responsiveness to constrictors and impaired action of vasodilators. Role of blood viscosity in the pathogenesis of hypertension is doubtful due to the lack of consistency in the studies. Incidence of hypertension can be reduced by achieving slow correction of anemia and by switching to subcutaneous route of administration. Conventional anti-hypertensives have been found to be beneficial in the treatment. In some severe and persistent cases, temporary discontinuation of erythropoietin may be needed.
贫血是某些慢性疾病的常见并发症，可通过刺激造血细胞以增加红细胞计数来治疗，而这一作用可通过重组人促红细胞生成素实现。在这篇综述文章中，我们讨论了促红细胞生成素治疗导致的高血压。我们探讨了促红细胞生成素诱导高血压的发病机制，并讨论了一些预防和治疗这种病症的方法。此外，还尝试探究血液粘度在促红细胞生成素诱导高血压中的作用。我们通过从PubMed和谷歌学术等在线数据库收集数据，对文献进行了全面综述。我们主要研究了揭示促红细胞生成素所致高血压机制的临床试验。高血压主要是由于血管对收缩剂的反应性增强以及血管舒张剂作用受损所致。由于研究结果缺乏一致性，血液粘度在高血压发病机制中的作用尚不确定。通过缓慢纠正贫血以及改用皮下给药途径，可降低高血压的发生率。已发现传统抗高血压药物在治疗中有益。在一些严重且持续的病例中，可能需要暂时停用促红细胞生成素。
