Department of Psychological and Brain Sciences, University of Iowa.
Behav Neurosci. 2021 Jun;135(3):343-346. doi: 10.1037/bne0000441. Epub 2021 Feb 25.
Previous studies found that inactivation of the central amygdala (CeA) severely impaired acquisition of cerebellum-dependent delay eye-blink conditioning (EBC) in male rats and rabbits. Sex differences in EBC and the effects of stress on EBC have been reported and might be related to sex differences in amygdala modulation of cerebellar learning. The current study examined the effects of CeA inactivation with muscimol on acquisition and retention of EBC in female rats. Like male rats, CeA inactivation in female rats severely impaired EBC acquisition and retention. Comparison of the female data with previously published data from males indicates no substantive sex differences in the effects of CeA inactivation on acquisition or retention of EBC. The results indicate that amygdala modulation of cerebellar learning is not sex-specific. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
先前的研究发现，中央杏仁核（CeA）的失活严重损害了雄性大鼠和兔子小脑依赖的延迟眼跳条件反射（EBC）的获得。已经报道了 EBC 中的性别差异以及应激对 EBC 的影响，这可能与杏仁核对小脑学习的调节中的性别差异有关。本研究用 muscimol 研究了 CeA 失活对雌性大鼠 EBC 获得和保持的影响。与雄性大鼠一样，雌性大鼠的 CeA 失活严重损害了 EBC 的获得和保持。将女性数据与之前发表的男性数据进行比较表明，CeA 失活对 EBC 的获得或保持没有实质性的性别差异。研究结果表明，杏仁核对小脑学习的调节没有性别特异性。（PsycInfo 数据库记录（c）2021 APA，保留所有权利）。
