Mozaffari Hamid Reza, Rostamnia Maryam, Sharifi Roohollah, Safaei Mohsen, Zavattaro Elisa, Tadakamadla Santosh Kumar, Imani Mohammad Moslem, Sadeghi Masoud, Golshah Amin, Moradpoor Hedaiat, Rezaei Farzad, Omidpanah Neda, Hatami Masoud
Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah 6713954658, Iran.
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran.
Gene. 2021 May 20;781:145524. doi: 10.1016/j.gene.2021.145524. Epub 2021 Feb 23.
Oral Cancer (OC) is one of the leading causes of death and the disease mainly occurs over 50 years of age. Herein, a meta-analysis aimed to assess the association between X-ray repair cross complementing (XRCC) polymorphisms and OC risk.
Four databases were searched extensively until June 5, 2020. Subgroup analysis, meta-regression, and funnel plots, as well as the quality assessment were estimated.
Fifteen studies were entered to the analysis. With regards to allele, homozygote, heterozygote, recessive, and dominant models, the pooled ORs for XRCC1 rs1799782 polymorphism were 1.51 (P = 0.01), 1.45 (P = 0.11), 1.45 (P = 0.0003), 1.44 (P = 0.0002), and 1.29 (P = 0.26); for XRCC1 rs1799782 polymorphism were 1.65 (P = 0.11), 1.50 (P = 0.33), 1.06 (P = 0.83), 1.57 (P = 0.12), and 1.32 (P = 0.45); for XRCC1 rs25489 polymorphism were 0.01 (P = 0.19), 1.44 (P = 0.48), 1.21 (P = 0.72), 1.17 (P = 0.19), and 1.38 (P = 0.54); for XRCC2 rs2040639 polymorphism were 0.68 (P = 0.0002), 0.63 (P = 0.02), 0.95 (P = 0.92), 0.79 (P = 0.49), and 0.61 (P = 0.005); and for XRCC3 rs861539 polymorphism were 1.24 (P = 0.20), 1.28 (P = 0.48), 0.99 (P = 0.95), 1.15 (P = 0.46), and 1.52 (P = 0.15), respectively.
The T allele and CT genotype of XRCC1 rs1799782 polymorphism had an elevated risk, whereas the G allele and GG genotype of XRCC2 rs2040639 polymorphism had a protective role in OC.
口腔癌（OC）是主要死因之一，该疾病主要发生于50岁以上人群。在此，一项荟萃分析旨在评估X射线修复交叉互补（XRCC）基因多态性与口腔癌风险之间的关联。
广泛检索四个数据库直至2020年6月5日。进行亚组分析、荟萃回归、漏斗图分析以及质量评估。
15项研究纳入分析。关于等位基因、纯合子、杂合子、隐性和显性模型，XRCC1 rs1799782基因多态性的合并比值比分别为1.51（P = 0.01）、1.45（P = 0.11）、1.45（P = 0.0003）、1.44（P = 0.0002）和1.29（P = 0.26）；XRCC1 rs1799782基因多态性的合并比值比分别为1.65（P = 0.11）、1.50（P = 0.33）、1.06（P = 0.83）、1.57（P = 0.12）和1.32（P = 0.45）；XRCC1 rs25489基因多态性的合并比值比分别为0.01（P = 0.19）、1.44（P = 0.48）、1.21（P = 0.72）、1.17（P = 0.19）和1.38（P = 0.54）；XRCC2 rs2040639基因多态性的合并比值比分别为0.68（P = 0.0002）、0.63（P = 0.02）、0.95（P = 0.92）、0.79（P = 0.49）和0.61（P = 0.005）；XRCC3 rs861539基因多态性的合并比值比分别为1.24（P = 0.20）、1.28（P = 0.48）、0.99（P = 0.95）、1.15（P = 0.46）和1.52（P = 0.15）。
XRCC1 rs1799782基因多态性的T等位基因和CT基因型具有较高风险，而XRCC2 rs2040639基因多态性的G等位基因和GG基因型在口腔癌中具有保护作用。
