Mohammad Shadab, Farooqui Sana, Srivastava Saurabh, Siang Tan Ching, Sridhar Sathvik Belagodu, Ahmad Irfan, Alamri Saad
Department of Oral & Maxillofacial Surgery, King George's Medical University, Lucknow, UP India.
School of Pharmacy, KPJ Healthcare University College, Nilai, Malaysia.
J Maxillofac Oral Surg. 2024 Aug;23(4):808-815. doi: 10.1007/s12663-024-02234-0. Epub 2024 Jun 15.
This study aimed to explore genetic variations associated with DNA repair mechanisms to enhance the management of both oral cancer (OC) and oral precancer (OPC).
A cohort of 380 patients diagnosed with OC and OPC, comprising 220 males and 160 females, was analyzed. Participants were categorized based on their tobacco-chewing habits, with corresponding control groups established. Key genetic markers investigated for polymorphisms included OGG1, APE1, and XRCC1.
The XRCC1 Arg280H variant demonstrated significant associations with the susceptibility to both OC and OPC across various models. Further analyses, incorporating factors such as tobacco and alcohol consumption, unveiled a correlation between the XRCC1 Arg194Trp variant and an elevated risk of developing head and neck cancer. Stratified analyses also revealed an increased risk of OC or OPC based on the specific site of the cancer.
The study underscores the importance of XRCC1 polymorphisms, particularly XRCC1 Arg280H and XRCC1 Arg194Trp, within the genetic framework of OC and OPC. Understanding these genetic associations provides valuable insights for the potential development of targeted interventions aimed at individuals predisposed to these conditions.
本研究旨在探索与DNA修复机制相关的基因变异，以加强口腔癌（OC）和口腔癌前病变（OPC）的管理。
对380例诊断为OC和OPC的患者进行队列分析，其中包括220名男性和160名女性。参与者根据其咀嚼烟草的习惯进行分类，并建立相应的对照组。研究的关键基因标记的多态性包括OGG1、APE1和XRCC1。
XRCC1 Arg280H变异在各种模型中均显示出与OC和OPC易感性显著相关。进一步纳入烟草和酒精消费等因素的分析揭示了XRCC1 Arg194Trp变异与头颈癌发病风险升高之间的相关性。分层分析还显示，根据癌症的特定部位，OC或OPC的风险增加。
该研究强调了XRCC1多态性，特别是XRCC1 Arg280H和XRCC1 Arg194Trp，在OC和OPC基因框架中的重要性。了解这些基因关联为针对易患这些疾病的个体开发靶向干预措施提供了有价值的见解。
