Institute for Policy Research, Northwestern University, Evanston, Illinois; Department of Psychology, Northwestern University, Evanston, Illinois.
Center for Family Research, University of Georgia, Athens Georgia.
Biol Psychiatry. 2019 Jul 15;86(2):153-162. doi: 10.1016/j.biopsych.2019.03.968. Epub 2019 May 1.
Researchers document bidirectional pathways linking peripheral inflammation and neural circuitries subserving emotion processing and regulation. To extend this work, we present results from two independent studies examining the relationship between inflammation and resting-state functional connectivity (rsFC), as measured by functional magnetic resonance imaging.
Study 1 involved 90 rural African American young adults, 25 years of age (52% female), and study 2 involved 82 urban African American youths, 13 to 14 years of age (66% female). Both studies measured circulating inflammatory biomarkers (C-reactive protein, interleukin 6, interleukin 10, tumor necrosis factor alpha), and the measures were averaged to form a composite. Study 2 also enumerated classical monocytes, a key leukocyte subpopulation involved in immune-to-brain signaling. All participants completed a resting-state functional magnetic resonance imaging scan.
Consistent with our prediction, higher scores on the inflammatory composite were associated with lower rsFC within an emotion regulation network in study 1, controlling for sex. Study 2 replicated study 1, showing that higher scores on the inflammatory composite were associated with lower rsFC within the emotion regulation network, controlling for sex, age, and pubertal status, and found a similar pattern for rsFC within a central executive network. Study 2 also found that higher numbers of classical monocytes were associated with lower rsFC within both the emotion regulation and central executive networks. There was no relationship between rsFC in the anterior salience or default mode networks with inflammation in either study.
With these findings, we document relationships between peripheral inflammation and rsFC within an emotion regulation and central executive network and replicate these associations with the emotion regulation network across two independent samples.
研究人员记录了外周炎症与情绪处理和调节所涉及的神经回路之间的双向关联。为了扩展这项工作，我们呈现了两项独立研究的结果，这些研究检查了炎症与静息态功能连接（rsFC）之间的关系，rsFC 通过功能磁共振成像来测量。
研究 1 涉及 90 名农村非裔美国年轻成年人，年龄 25 岁（52%为女性），研究 2 涉及 82 名城市非裔美国青少年，年龄 13 至 14 岁（66%为女性）。两项研究均测量了循环炎症生物标志物（C 反应蛋白、白细胞介素 6、白细胞介素 10、肿瘤坏死因子 α），并对这些测量值进行平均以形成一个综合指标。研究 2 还计算了经典单核细胞的数量，经典单核细胞是一种参与免疫向大脑信号传递的关键白细胞亚群。所有参与者都完成了静息态功能磁共振成像扫描。
与我们的预测一致，炎症综合指标得分较高与研究 1 中情绪调节网络内的 rsFC 降低有关，控制了性别因素。研究 2 复制了研究 1 的结果，表明炎症综合指标得分较高与情绪调节网络内的 rsFC 降低有关，控制了性别、年龄和青春期状态，并且在中央执行网络内也发现了类似的 rsFC 模式。研究 2 还发现，经典单核细胞数量较高与情绪调节和中央执行网络内的 rsFC 降低有关。在前注意和默认模式网络中 rsFC 与炎症之间没有关系。
有了这些发现，我们记录了外周炎症与情绪调节和中央执行网络内 rsFC 之间的关系，并在两个独立样本中复制了这些与情绪调节网络的关联。
