Shiseido Global Innovation Center, Yokohama, Japan.
Shiseido Global Innovation Center, Yokohama, Japan.
Biochem Biophys Res Commun. 2021 Apr 9;548:1-6. doi: 10.1016/j.bbrc.2021.02.050. Epub 2021 Feb 22.
Malodorous compounds induce stress responses, mood changes, an increase of skin conductance, activation of the sympathetic nervous system and other physiological changes, and it has been suggested that sensing malodors could provide warning of danger to health. Furthermore, the human body secretes various malodorous compounds as waste products of metabolism, including trans-2-nonenal ((E)-2-nonenal), the amount of which increases with aging. In the present study, we examined the effects of some endogenous malodorous compounds ((E)-2-nonenal, nonanal, pentanal, hexanal, hexanoic acid, hexylamine and isovaleric acid) on cultured human keratinocytes. (E)-2-Nonenal decreased the viability and promoted apoptosis of cultured keratinocytes. It also reduced the thickness and the number of proliferative cells in a three-dimensional epidermal equivalent model. Co-application of masking odorants (dihydromycenol, benzaldehyde, linalool, phenethyl alcohol, benzyl acetate and anisaldehyde), but not non-masking odorants (1,8-cineol, β-damascone, and o-t-butylcyclohexyl acetate), reduced the effect of (E)-2-nonenal on keratinocyte proliferation, and restored the thickness and number of proliferative cells in a three-dimensional epidermal equivalent model.
有气味的化合物会引起应激反应、情绪变化、皮肤电导率增加、交感神经系统激活和其他生理变化，有人认为感知异味可以提供对健康危害的警告。此外，人体会分泌各种有气味的化合物作为新陈代谢的废物，包括反式-2-壬烯醛((E)-2-壬烯醛)，其含量随着年龄的增长而增加。在本研究中，我们研究了一些内源性有气味化合物((E)-2-壬烯醛、壬醛、戊醛、己醛、己酸、己胺和异戊酸)对培养的人角质形成细胞的影响。(E)-2-壬烯醛降低了培养角质形成细胞的活力并促进了其凋亡。它还减少了三维表皮等效模型中细胞的厚度和增殖细胞的数量。掩蔽气味剂（二氢月桂烯醇、苯甲醛、芳樟醇、苯乙醇、乙酸苄酯和茴香醛）的共同应用（但非掩蔽气味剂（1,8-桉树脑、β-大马酮和 o-t-丁基环己基乙酸酯）降低了(E)-2-壬烯醛对角质形成细胞增殖的影响，并恢复了三维表皮等效模型中细胞的厚度和数量。
