Lyu W H, Xia F, Zhou C S, Huang M, Ding W W, Zhang S, Liu F, Ma J C, Li X L, Yu Y Z, Zhang L J, Lu G M
Department of Medical Imaging, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, China.
Department of General Surgery, Jinling Hospital, Southern Medical University, Nanjing 210002, China.
Zhonghua Yi Xue Za Zhi. 2021 Feb 23;101(7):481-486. doi: 10.3760/cma.j.cn112137-20201117-03123.
To investigate the diagnostic efficacy and potential application value of deep learning-based chest CT auxiliary diagnosis system in emergency trauma patients. A total of 403 patients, including 254 males and 149 females aged from 16 to 100 (50±19) years, who received emergency treatment for trauma and chest CT examination in the Eastern Theater General Hospital from September 2019 to November 2019 were retrospectively analyzed. Dr. Wise Lung Analyzer's chest CT auxiliary diagnosis system was applied to detect 5 types of injuries, including pneumothorax, pleural effusion/hemothorax, pulmonary contusion (shown as consolidation and ground glass opacity), rib fractures, and other fractures (including thoracic vertebrae, sternum, scapula and clavicle, etc.) and 6 other abnormalities (bullae, emphysema, pulmonary nodules, stripe, reticulation, pleural thickening). The diagnostic reference standards were labeled by two radiologists independently. The sensitivity and specificity of the auxiliary diagnosis system were evaluated. The imaging diagnostic reports were compared with the results of the auxiliary diagnosis system, and the diagnostic consistency between the two was calculated by using the Kappa test. According to the reference standards, among the 403 patients, 29 were pneumothorax, 75 were pleural effusion/hemothorax, 131 were pulmonary contusion, 124 were rib fractures, and 63 were other fractures. The sensitivity and specificity of the auxiliary diagnosis system for detection of pneumothorax, pleural effusion/hemothorax, rib fractures, and other fractures were 96.6%, 97.6%, 80.0%, 99.7%, 99.2%, 83.9%, 84.1%, and 99.7%, respectively. The sensitivity of detecting lung contusion was 97.7%. There was a high consistency between the auxiliary diagnosis system and imaging diagnosis in the diagnosis of injuries, in which the kappa values of pneumothorax, pleural effusion, rib fracture and other fractures were 0.783, 0.821, 0.706 and 0.813, respectively (all <0.001). Two cases of pneumothorax, three cases of pleural effusion/hemothorax, nine cases of rib fractures, and six cases of other fractures missed by imaging diagnosis were all detected by the auxiliary diagnosis system. The detection sensitivity of the auxiliary diagnosis system was higher for emphysema, pulmonary nodules and stripe (all>85%), but lower for bullae, reticulation and pleural thickening. The deep learning-based chest CT auxiliary diagnosis system could effectively assist chest CT to detect injuries in emergency trauma patients, which was expected to optimize the clinical workflow.
探讨基于深度学习的胸部CT辅助诊断系统在急诊创伤患者中的诊断效能及潜在应用价值。回顾性分析2019年9月至2019年11月在东部战区总医院接受创伤急救及胸部CT检查的403例患者,其中男性254例,女性149例,年龄16至100岁(50±19岁)。应用Wise Lung Analyzer胸部CT辅助诊断系统检测气胸、胸腔积液/血胸、肺挫伤(表现为实变和磨玻璃影)、肋骨骨折及其他骨折(包括胸椎、胸骨、肩胛骨和锁骨等)5种损伤以及大疱、肺气肿、肺结节、条索、网状影、胸膜增厚6种其他异常情况。诊断参考标准由两名放射科医生独立标注,评估辅助诊断系统的敏感性和特异性。将影像诊断报告与辅助诊断系统结果进行比较,采用Kappa检验计算两者之间的诊断一致性。根据参考标准,403例患者中,气胸29例,胸腔积液/血胸75例,肺挫伤131例,肋骨骨折124例,其他骨折63例。辅助诊断系统检测气胸、胸腔积液/血胸、肋骨骨折及其他骨折的敏感性和特异性分别为96.6%、97.6%、80.0%、99.7%、99.2%、83.9%、84.1%和99.7%。检测肺挫伤的敏感性为97.7%。辅助诊断系统与影像诊断在损伤诊断方面具有较高一致性,其中气胸、胸腔积液、肋骨骨折及其他骨折的kappa值分别为0.783、0.821、0.706和0.813(均<0.001)。影像诊断漏诊的2例气胸、3例胸腔积液/血胸、9例肋骨骨折及6例其他骨折均被辅助诊断系统检测出。辅助诊断系统对肺气肿、肺结节及条索的检测敏感性较高(均>85%),对大疱、网状影及胸膜增厚的检测敏感性较低。基于深度学习的胸部CT辅助诊断系统可有效辅助胸部CT检测急诊创伤患者的损伤情况,有望优化临床工作流程。