脑和睾丸中的剪接调控：高度特化器官的共同主题。
Splicing regulation in brain and testis: common themes for highly specialized organs.
机构信息
Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, Rome, Italy.
Organoids Facility, IRCCS Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
出版信息
Cell Cycle. 2021 Mar-Mar;20(5-6):480-489. doi: 10.1080/15384101.2021.1889187. Epub 2021 Feb 26.
Abstract
Expansion of the coding and regulatory capabilities of eukaryotic transcriptomes by alternative splicing represents one of the evolutionary forces underlying the increased structural complexity of metazoans. Brain and testes stand out as the organs that mostly exploit the potential of alternative splicing, thereby expressing the largest repertoire of splice variants. Herein, we will review organ-specific as well as common mechanisms underlying the high transcriptome complexity of these organs and discuss the impact exerted by this widespread alternative splicing regulation on the functionality and differentiation of brain and testicular cells.
摘要
通过选择性剪接扩展真核转录组的编码和调控能力，是后生动物结构复杂性增加的进化驱动力之一。大脑和睾丸是最能挖掘选择性剪接潜能的器官，从而表达最大的剪接变体谱。本文将综述这些器官高转录组复杂性的组织特异性和共同机制，并讨论这种广泛存在的选择性剪接调控对脑和睾丸细胞功能和分化的影响。
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