还原性甘氨酸途径：一碳生物技术的通用途径
Reductive Glycine Pathway: A Versatile Route for One-Carbon Biotech.
作者信息
Claassens Nico J
机构信息
Laboratory of Microbiology, Wageningen University, Stippeneng 4, 6708, WE, Wageningen, The Netherlands.
出版信息
Trends Biotechnol. 2021 Apr;39(4):327-329. doi: 10.1016/j.tibtech.2021.02.005. Epub 2021 Feb 23.
Abstract
Hong et al. heterologously expressed the metabolic core of the reductive glycine pathway (rGlyP) as a sink for the anaerobic conversion of glycerol. This recent study concludes several reports in 2020 on the ATP-efficient, one-carbon-assimilating rGlyP. Its engineering in diverse hosts could help the transformation toward renewable, one-carbon-based bioproduction.
摘要
洪等人异源表达了还原性甘氨酸途径（rGlyP）的代谢核心，作为甘油厌氧转化的一个汇。这项最新研究总结了2020年关于高效ATP、一碳同化rGlyP的几篇报告。在不同宿主中对其进行工程改造有助于向可再生的、基于一碳的生物生产转变。
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