由basigin介导的新冠病毒可影响男性和女性的生育能力。
COVID-19 Mediated by Basigin Can Affect Male and Female Fertility.
作者信息
Mahdian Soodeh, Shahhoseini Maryam, Moini Ashraf
机构信息
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
出版信息
Int J Fertil Steril. 2020 Oct;14(3):262-263. doi: 10.22074/ijfs.2020.134702. Epub 2020 Oct 12.
Coronavirus disease 2019 (COVID-19) prevalence has caused many problems in society and disrupted many regular aspects of life. COVID-19 contains major structural proteins that among them, S protein can promote fusion of the viral and cellular membranes and facilitate the entry of coronavirus into the host cells. Basigin (BSG) is one of the most important receptors for COVID-19 that mediates its entry to host cells. Also, Basigin has an important role in male and female reproduction. Basigin is expressed in the uterus and plays an important role during embryo implantation and needed for successful implantation. Therefore, disruption or inhibition of Basigin causes to a weakness in embryo implantation. Therefore, if a woman or a man is infected with COVID-19, it is recommended that they do not attempt to conception until their treatment is complete. It is also recommended tests for COVID-19 be performed on infertile couples before using assisted reproductive technology (ART).
2019冠状病毒病（COVID-19）的流行给社会带来了诸多问题，并扰乱了许多正常的生活方面。COVID-19包含主要结构蛋白，其中S蛋白可促进病毒膜与细胞膜融合，并有助于冠状病毒进入宿主细胞。基底膜蛋白（BSG）是COVID-19最重要的受体之一，介导其进入宿主细胞。此外，基底膜蛋白在男性和女性生殖中也具有重要作用。基底膜蛋白在子宫中表达，在胚胎着床过程中起重要作用，是成功着床所必需的。因此，基底膜蛋白的破坏或抑制会导致胚胎着床能力减弱。因此，如果女性或男性感染了COVID-19，建议在治疗结束前不要尝试受孕。还建议在使用辅助生殖技术（ART）之前，对不孕夫妇进行COVID-19检测。
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