沙特阿拉伯东部省份乳腺癌患者预后和预测指标的相关性。

Correlation of prognostic and predictive indicators in breast cancer patients from the eastern province of Saudi Arabia.

机构信息

From the Pathology Department, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Kingdom of Saudi Arabia.

出版信息

Saudi Med J. 2021 Mar;42(3):293-298. doi: 10.15537/smj.2021.42.3.20200711.

DOI:10.15537/smj.2021.42.3.20200711

PMID:33632908

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7989269/

Abstract

OBJECTIVES

To highlight and correlate demographic and histopathological features of breast cancer along with prognostic and predictive biomarkers, in Saudi patients from the Eastern Province and compare it to a cohort of non-Saudi patients.

METHODS

In a retrospective study between January 1998 and December 2017, data were collected from the medical records of breast cancer patients who were admitted at King Fahd University Hospital (KFHU), Dammam, Saudi Arabia. The information included demographic, histopathological, and immunohistochemical findings.

RESULTS

Out of 482 breast cancer patients, 60% (n=286) were Saudis, and 40% (n=196) were non-Saudis. Data showed a wide age distribution; however, most cases (80%) were seen in the third through fifth decades, with a median age at diagnosis of 51 ±12 years. Over years, breast cancer in Saudi patients was increasingly seen at a younger age (=0.003). While tumors were increasingly detected at earlier stages (=0.003); however, stage III & IV tumors (=0.033) and human epidermal growth factor receptor-2 overexpressed tumors (=0.035) were more frequently seen at a younger age. Interestingly, these associations were not significant in non-Saudi patients.

CONCLUSION

Although, the current findings might help future studies to identify variables that could lead to better management of breast cancer in this region; however, a wider investigation including other centers in the eastern province is needed.

摘要

目的

突出并关联沙特东部省份乳腺癌患者的人口统计学和组织病理学特征以及预后和预测生物标志物，并将其与非沙特患者队列进行比较。

方法

在 1998 年 1 月至 2017 年 12 月的回顾性研究中，从沙特阿拉伯达曼法赫德国王大学医院（KFHU）入院的乳腺癌患者的病历中收集数据。信息包括人口统计学、组织病理学和免疫组织化学发现。

结果

在 482 例乳腺癌患者中，60%（n=286）为沙特人，40%（n=196）为非沙特人。数据显示年龄分布广泛；然而，大多数病例（80%）见于第三至第五个十年，诊断时的中位年龄为 51±12 岁。多年来，沙特患者的乳腺癌发病年龄越来越年轻（=0.003）。虽然肿瘤越来越早地被发现（=0.003）；然而，III 期和 IV 期肿瘤（=0.033）和人表皮生长因子受体-2 过表达肿瘤（=0.035）在较年轻时更常见。有趣的是，这些关联在非沙特患者中并不显著。