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瓜维亚库病毒，一种从巴西两种伊蚊中分离出来的新型昆虫特异性黄病毒。

Guapiaçu virus, a new insect-specific flavivirus isolated from two species of Aedes mosquitoes from Brazil.

机构信息

Institute of Biological Sciences, Federal University of Pará, Belém, Pará, 66075-000, Brazil.

Institute of Tropical Medicine, University of São Paulo, São Paulo, SP, 05403-000, Brazil.

出版信息

Sci Rep. 2021 Feb 25;11(1):4674. doi: 10.1038/s41598-021-83879-6.

DOI:10.1038/s41598-021-83879-6
PMID:33633167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7907106/
Abstract

Classical insect-flaviviruses (cISFVs) and dual host-related insect-specific flavivirus (dISFV) are within the major group of insect-specific flavivirus. Remarkably dISFV are evolutionarily related to some of the pathogenic flavivirus, such as Zika and dengue viruses. The Evolutionary relatedness of dISFV to flavivirus allowed us to investigate the evolutionary principle of host adaptation. Additionally, dISFV can be used for the development of flavivirus vaccines and to explore underlying principles of mammalian pathogenicity. Here we describe the genetic characterization of a novel putative dISFV, termed Guapiaçu virus (GUAPV). Distinct strains of GUAPV were isolated from pools of Aedes terrens and Aedes scapularis mosquitoes. Additionally, we also detected viral GUAPV RNA in a plasma sample of an individual febrile from the Amazon region (North of Brazil). Although GUAPV did not replicate in tested mammalian cells, 3'UTR secondary structures duplication and codon usage index were similar to pathogenic flavivirus.

摘要

经典昆虫黄病毒（cISFVs）和双宿主相关昆虫特异性黄病毒（dISFV）属于昆虫特异性黄病毒的主要组群。值得注意的是，dISFV 在进化上与一些致病性黄病毒（如寨卡病毒和登革热病毒）有关。dISFV 与黄病毒的进化关系使我们能够研究宿主适应的进化原则。此外，dISFV 可用于黄病毒疫苗的开发，并探索哺乳动物致病性的潜在原理。在这里，我们描述了一种新型推定的 dISFV，称为瓜皮阿苏病毒（GUAPV）的遗传特征。从 Aedes terrens 和 Aedes scapularis 蚊子的池中分离出不同的 GUAPV 株。此外，我们还在来自亚马逊地区（巴西北部）发热个体的血浆样本中检测到了 GUAPV RNA。尽管 GUAPV 未在测试的哺乳动物细胞中复制，但 3'UTR 二级结构重复和密码子使用指数与致病性黄病毒相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/75da8e62543f/41598_2021_83879_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/dc73e39804aa/41598_2021_83879_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/89f37fc8ad22/41598_2021_83879_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/0155d8f77d0a/41598_2021_83879_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/75da8e62543f/41598_2021_83879_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/dc73e39804aa/41598_2021_83879_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/ca8bc134dfca/41598_2021_83879_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/54117d24805b/41598_2021_83879_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/e589db6eb41a/41598_2021_83879_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/89f37fc8ad22/41598_2021_83879_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/0155d8f77d0a/41598_2021_83879_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb16/7907106/75da8e62543f/41598_2021_83879_Fig7_HTML.jpg

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