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生物制剂在食物过敏管理中的应用。

Use of biologics in food allergy management.

作者信息

Worm Margitta, Francuzik Wojciech, Dölle-Bierke Sabine, Alexiou Aikaterina

机构信息

Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergy, Charité - Universitätsmedizin Berlin, Germany.

出版信息

Allergol Select. 2021 Feb 19;5:103-107. doi: 10.5414/ALX02141E. eCollection 2021.

Abstract

Food allergies are a common medical problem, with children being the most affected patient group. The standard of care of food allergy consists of the acute treatment in case of a reaction and food avoidance in the long term, which influences the quality of life of patients. In this article, current developments for the causal treatment of food allergy including specific immunotherapy and biologics will be discussed. Epicutaneous and oral immunotherapy are currently in clinical development for the treatment of food allergy, and the results demonstrate good tolerability and efficacy with an increase in the oral threshold level. Biologics and, in particular, anti-IgE are currently investigated for their therapeutic use in food allergies. The results are promising, suggesting efficacy and tolerability.

摘要

食物过敏是一个常见的医学问题,儿童是受影响最严重的患者群体。食物过敏的治疗标准包括反应时的急性治疗和长期的食物回避,这会影响患者的生活质量。在本文中,将讨论食物过敏病因治疗的当前进展,包括特异性免疫疗法和生物制剂。经皮免疫疗法和口服免疫疗法目前正处于治疗食物过敏的临床开发阶段,结果显示出良好的耐受性和疗效,口服阈值水平有所提高。目前正在研究生物制剂,特别是抗IgE在食物过敏治疗中的应用。结果很有前景,表明其有效性和耐受性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3e4/7901360/3d93c4b20054/allergologieselect-5-103-01.jpg

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