Research Center in Physical Activity Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal.
Research Institute of Hospital 12 de Octubre ('i+12'), Madrid, Spain.
Int J Sports Med. 2021 Sep;42(10):924-929. doi: 10.1055/a-1342-7347. Epub 2021 Feb 25.
Colorectal cancer is now a frequently treatable illness for most and a chronic disease for many. The number of people living with a diagnosis of colorectal cancer is thus expected to rise. Yet even after successful treatment, colorectal cancer survivors, mostly the elderly, frequently experience health problems and impaired health-related quality of life. We investigated the cross-sectional association between physical fitness, measured with the 6-min walk test, 30-second chair-stand test, and isometric handgrip strength, as well as health-related quality of life, in a cohort of colorectal cancer patients (n=71, mean [SD] age 67±10 years, 63% men; 35, 39 and 25% in stages I, II and III, respectively). Greater performance in the 6-minute walk test and 30-second chair-stand test was associated with higher levels of global health status (p<0.001, p=0.001 respectively), higher functioning (p<0.001) and lower levels of symptomatology (p<0.001; pain and fatigue). Additionally, greater 6-min walk test performance was associated with a better cognitive function (p=0.005). Our results suggest that greater aerobic fitness and lower-extremity muscle strength are cross-sectionally associated with higher levels of global health status, higher functioning and lower levels of symptomatology such as pain and fatigue in colorectal cancer patients.
结直肠癌现在对大多数人来说是一种可治疗的疾病，对许多人来说是一种慢性病。因此，预计患有结直肠癌的人数将会增加。然而，即使经过成功的治疗，结直肠癌幸存者，大多数是老年人，经常会遇到健康问题和健康相关的生活质量受损。我们调查了在结直肠癌患者队列中（n=71，平均[SD]年龄 67±10 岁，63%为男性；分别为 35%、39%和 25%处于 I、II 和 III 期），身体素质（通过 6 分钟步行测试、30 秒椅站立测试和等速握力测量）与健康相关的生活质量之间的横断面关联。6 分钟步行测试和 30 秒椅站立测试的表现更好与更高的全球健康状况评分（p<0.001，p=0.001）、更高的功能状态（p<0.001）和更低的症状评分（p<0.001；疼痛和疲劳）相关。此外，6 分钟步行测试表现更好与更好的认知功能（p=0.005）相关。我们的研究结果表明，有氧健身和下肢肌肉力量更强与结直肠癌患者更高的全球健康状况评分、更高的功能状态和更低的症状评分（如疼痛和疲劳）相关。
