Esteva Magdalena, March Sebastià, Martín-Rabadan María, Torres-Solera Elena, Ripoll Joana
Majorca Department of Primary Care, Unit of Research, Baleares Health Service [IbSalut], Escola Graduada 3, 07002, Palma, Majorca, Spain.
Health Research Institute of the Balearic Islands (IdISBa), Edificio S, Hospital Son Espases, Carretera de Valldemossa, 79, 07120, Palma, Majorca, Spain.
Clin Transl Oncol. 2025 Apr 29. doi: 10.1007/s12094-025-03930-0.
To compare the long-term health status of a group of survivors of colorectal cancer (CRC) with a reference group of individuals who did not have cancer. We determined the physical, mental, and general health-related quality of life (HRQoL); overall morbidities and CRC-specific morbidities related to the delayed effects of treatment; and maintenance of a healthy lifestyle in these two groups.
This descriptive cross-sectional study was conducted from 2016 to 2019 in the Balearic Islands (Spain). CRC patients who were diagnosed from 2011 to 2012 and survived at least 5 years were randomly selected from the Majorca and Eivissa-Formentera cancer registries. The reference group consisted of individuals matched for gender and age who had no history of cancer.
We examined 201 CRC survivors and 199 matched individuals without cancer. The global analysis showed that the two groups had similar scores in the physical and mental components of the Short Form 12 (SF-12) HRQoL scale and in general health status. The CRC survivors had significantly higher prevalence of general comorbidity and CRC-specific comorbidity. Multivariate analyses and calculation of odds ratios (ORs) showed that the groups had similar physical HRQoL (Model 1, OR: 1.01, 95% CI: 0.99-1.03), mental HRQoL (Model 2, OR: 0.99, 95% CI: 0.66-1.01), and general HRQoL (Model 3, OR: 1.67, 95% CI: 0.39-1.13). However, the long-term CRC survivors had significantly greater ORs for an increased overall comorbidity index, number of CRC-specific comorbidity, and obesity in all three models (P < 0.05).
The CRC survivors and individuals without cancer had similar HRQoL, suggesting that CRC survivors do not need additional services that aim to improve HRQoL. Nonetheless, health care providers should be pro-active when caring for CRC survivors, because they are more likely to present with certain comorbidity and less likely to follow a healthy lifestyle.
比较一组结直肠癌（CRC）幸存者与一组无癌症个体的长期健康状况。我们测定了身体、心理和与总体健康相关的生活质量（HRQoL）；与治疗延迟效应相关的总体发病率和CRC特异性发病率；以及这两组人群健康生活方式的维持情况。
这项描述性横断面研究于2016年至2019年在西班牙巴利阿里群岛进行。从马略卡岛和伊维萨 - 福门特拉岛癌症登记处随机选取2011年至2012年确诊且存活至少5年的CRC患者。对照组由性别和年龄匹配且无癌症病史的个体组成。
我们检查了201名CRC幸存者和199名匹配的无癌症个体。整体分析表明，两组在简短健康调查问卷12项（SF - 12）HRQoL量表的身体和心理维度以及总体健康状况方面得分相似。CRC幸存者的总体合并症和CRC特异性合并症患病率显著更高。多变量分析和比值比（OR）计算表明，两组在身体HRQoL（模型1，OR：1.01，95%CI：0.99 - 1.03）、心理HRQoL（模型2，OR：0.99，95%CI：0.66 - 1.01）和总体HRQoL（模型3，OR：1.67，95%CI：0.39 - 1.13）方面相似。然而，在所有三个模型中，长期CRC幸存者的总体合并症指数增加、CRC特异性合并症数量增加和肥胖的OR值显著更高（P < 0.05）。
CRC幸存者和无癌症个体的HRQoL相似，这表明CRC幸存者不需要旨在改善HRQoL的额外服务。尽管如此，医疗保健提供者在照顾CRC幸存者时应积极主动，因为他们更有可能出现某些合并症，且遵循健康生活方式的可能性较小。
