Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hunan Key Laboratory of Ophthalmology, Changsha, Hunan, China.
J Cell Physiol. 2021 Oct;236(10):7097-7116. doi: 10.1002/jcp.30347. Epub 2021 Feb 26.
Noncoding ribonucleic acids (ncRNAs) are an increasingly studied class of RNA molecules with extensive biological activities, including important roles in human development, health, and disease. Glaucoma is a neurodegenerative disease of the retina, and one of the leading causes of blindness worldwide. However, the specific roles of ncRNAs in the development and progression of glaucoma are unclear, and related reports are fragmented. An in-depth understanding of ncRNAs participating in the pathogenesis and progression of glaucoma would be helpful for opening up new avenues to facilitate the early diagnosis and clinical treatment. Therefore, in this review, we aimed to discuss the current research progress, the potentialfuture clinical applications and the research limitations of three critical classes of ncRNAs in glaucoma, namely microRNAs, long noncoding RNAs, and circular RNAs.
非编码核糖核酸（ncRNAs）是一类日益受到研究关注的 RNA 分子，具有广泛的生物学活性，包括在人类发育、健康和疾病中发挥重要作用。青光眼是一种视网膜神经退行性疾病，是全球致盲的主要原因之一。然而，ncRNAs 在青光眼的发生和发展中的具体作用尚不清楚，相关报道也较为零散。深入了解参与青光眼发病机制和进展的 ncRNAs 将有助于开辟新的途径，促进早期诊断和临床治疗。因此，在本综述中，我们旨在讨论三种关键 ncRNAs（microRNAs、长非编码 RNA 和环状 RNA）在青光眼研究中的现状、潜在的未来临床应用及研究局限性。
