Özalp G R, Yavuz A, Seker I, Udum-Küçükşen D, Rişvanlı A, Korlu Y
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Uludag University, Bursa, Turkey.
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Uludag University, Bursa, Turkey.
Theriogenology. 2018 Aug;116:112-118. doi: 10.1016/j.theriogenology.2018.04.032. Epub 2018 May 4.
A new protocol with aglepristone to induce parturition in ewes with pregnancy toxemia has been reported in the present manuscript. Four experimental groups were defined: Group AG5 (n = 10), Group DEX (n = 10), Group NC (n = 5) and Group PT (n = 5) in which ewes were injected twice with 10 mg/kg of aglepristone and 5 ml dexamethasone in first two groups, respectively; whereas negative control and pregnancy toxemia groups received no treatment for parturition induction. Different clinical parameters associated with parturition in ewes and their newborns were investigated. Blood hematology and biochemical measurements were carried out both in ewes and lambs. Blood pH values of lambs were recorded during the study. The injection time-lambing time, injection time-vaginal discharge intervals, placental expulsion periods, placental weight and vaginal delivery interval between lambs, hematological and biochemical results were not statistically different among the groups (p > 0,05). Increased NEFA and β-HBA concentrations accompanied the disease and all ewes in AG, DEX and PT Groups developed clinical pregnancy toxemia (NEFA; P = 0,009) and β-HBA; (P = 0,039). The differences in rectal body temperature of lambs were not significant (p > 0,05), whereas birth weight was found statistically significant among groups (p < 0,05). Blood pH, biochemical and hematologic measurements of lambs had also significant differences depending on different time points. Parturition pathology by means of incomplete cervical dilatation was severely observed in DEX Group. The results of this study show that aglepristone application in pregnancy toxemia to induce parturition could precisely control lambing time without any side effects in either mothers or lambs. Apart from these, it could be speculated that dexamethasone seems to induce parturition causing crucial pathologies, which results in important and risky changes in newborns' life. Incomplete cervical dilatation and continued ineffective uterine contractions could be a major factor of newborn losses because of placental separation and cessation of blood supply.
本手稿报道了一种使用阿格孕酮诱导妊娠毒血症母羊分娩的新方案。定义了四个实验组：AG5组（n = 10）、DEX组（n = 10）、NC组（n = 5）和PT组（n = 5），前两组母羊分别注射两次10mg/kg的阿格孕酮和5ml地塞米松；而阴性对照组和妊娠毒血症组未接受诱导分娩治疗。研究了与母羊及其新生羔羊分娩相关的不同临床参数。对母羊和羔羊都进行了血液学和生化检测。在研究期间记录羔羊的血液pH值。各实验组之间的注射至产羔时间、注射至阴道排出物间隔、胎盘排出期、胎盘重量以及羔羊之间的阴道分娩间隔、血液学和生化结果均无统计学差异（p>0.05）。疾病伴有非酯化脂肪酸（NEFA）和β-羟基丁酸（β-HBA）浓度升高，AG组、DEX组和PT组的所有母羊均出现临床妊娠毒血症（NEFA；P = 0.009）和β-HBA；（P = 0.039）。羔羊直肠体温差异不显著（p>0.05），而出生体重在各实验组之间有统计学差异（p<0.05）。羔羊的血液pH值、生化和血液学检测结果在不同时间点也有显著差异。DEX组严重观察到因宫颈扩张不全导致的分娩病理情况。本研究结果表明，在妊娠毒血症中应用阿格孕酮诱导分娩可精确控制产羔时间，且对母羊或羔羊均无任何副作用。除此之外，可以推测地塞米松似乎诱导分娩并导致关键病理情况，从而在新生羔羊的生命中产生重要且危险的变化。宫颈扩张不全和持续无效的子宫收缩可能是由于胎盘分离和血液供应停止导致新生羔羊死亡的主要因素。
