Taek Maximus M, Tukan Gerardus D, Prajogo Bambang E W, Agil Mangestuti
Widya Mandira Catholic University Faculty of Mathematics and Natural Sciences, Department of Chemistry, Kupang, Indonesia.
Airlangga University Faculty of Pharmacy, Department of Pharmacognosy and Phytochemistry, Surabaya, Indonesia.
Turk J Pharm Sci. 2021 Feb 25;18(1):80-90. doi: 10.4274/tjps.galenos.2019.29000.
To document traditional antimalarial plants used by Tetun ethnic people in West Timor Indonesia and evaluate the antiplasmodial activity and phytochemicals of several plants that are widely used as oral medicine.
A field study to document antimalarial plants followed by laboratory works to test antiplasmodial activity and identify the phytochemical constituents of some selected plants extract were applied. The inhibitory potency of ethanolic extracts of wood, roots of , , and , whole plant of and , stem barks of , , and , and leaves of on the 3D7 strain were tested. Gas chromatography-mass spectrometry instrument was used to analyze the phytochemicals of the extracts.
The Tetun ethnic people use 50 plant species as antimalarials. , , and extracts show strong antiplasmodial activity with IC values of 0.22, 0.22, and 1.23 μg/mL, respectively; , , , and were moderate antiplasmodials with IC values of 11.60, 15.46, 24.92, and 36.39 μg/mL, respectively; and , , , and were weak antiplasmodials with IC values of 54.25, 63.52, 63.91, and 66.49 μg/mL, respectively. The phytochemicals identification data indicate that these 11 plants contain alkaloids, terpenoids, steroids, coumarins, alcohols, thiols, phenolics, aldehydes, fatty acids, esters, and so forth.
Plants widely used as antimalarials by the Tetun ethnic people is proven to have antiplasmodial activity.
记录印度尼西亚西帝汶特顿族使用的传统抗疟植物，并评估几种广泛用作口服药物的植物的抗疟活性和植物化学成分。
开展一项记录抗疟植物的实地研究，随后进行实验室研究，以测试抗疟活性并鉴定一些选定植物提取物的植物化学成分。测试了来自 木、 根、 根、 根、 全株、 全株、 茎皮、 茎皮、 茎皮以及 叶的乙醇提取物对恶性疟原虫 3D7 株的抑制效力。使用气相色谱 - 质谱联用仪分析提取物的植物化学成分。
特顿族使用 50 种植物作为抗疟药。 提取物、 提取物和 提取物显示出较强的抗疟活性，IC50 值分别为 0.22、0.22 和 1.23 μg/mL； 提取物、 提取物、 提取物和 提取物为中等抗疟药，IC50 值分别为 11.60、15.46、24.92 和 36.39 μg/mL； 提取物、 提取物、 提取物和 提取物为弱抗疟药，IC50 值分别为 54.25、63.52、63.91 和 66.49 μg/mL。植物化学成分鉴定数据表明，这 11 种植物含有生物碱、萜类、甾体、香豆素、醇类、硫醇、酚类、醛类、脂肪酸、酯类等。
特顿族广泛用作抗疟药的植物被证明具有抗疟活性。
