Lemma Martha Tibebu, Ahmed Ali Mahmoud, Elhady Mohamed Tamer, Ngo Huyen Thi, Vu Tran Le-Huy, Sang To Kim, Campos-Alberto Eduardo, Sayed Abdelrahman, Mizukami Shusaku, Na-Bangchang Kesara, Huy Nguyen Tien, Hirayama Kenji, Karbwang Juntra
Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Faculty of Medicine, Al-Azhar University, Cairo 11884, Egypt.
Parasitol Int. 2017 Dec;66(6):713-720. doi: 10.1016/j.parint.2017.09.002. Epub 2017 Sep 7.
The increasing resistance of malaria to drugs raise the need to new antimalarial agents. Antiplasmodial herbs and their active compounds are the most promising source the new antimalarial agents. This study aimed to identify the medicinal plants with very good in vitro antiplasmodial activities, with half-maximal inhibitory concentration (IC)≤1μg/ml, and to determine trends in the process of screening their antiplasmodial activities. A total of 58 reports published in the English language were retrieved from the bibliographical databases. Screening and data extraction were performed by two independent reviewers. The herbs were categorized as very good, good, moderate and inactive if the IC values were <0.1μg/ml, 0.1-1μg/ml, >1-5μg/ml and >5μg/ml respectively. We documented 752 medicinal plants belonging to 254 genera. The majority of the plants were reported from Africa followed by Asia. The traditional use for malaria treatment was the most common reason for the selection of the plants for investigation. About 80% of the plants experimented were reported to be inactive. Among plants identified as having very good to good antiplasmodial crude extracts are Harungana madagascariensis, Quassia africana, and Brucea javanica, while Picrolemma spruce, Aspidosperma vargasi, Aspidosperma desmanthum, and Artemisia annua were reported to have individual compound isolates with very good antiplasmodial activities. In conclusion, the number of plant species assessed so far is still small compared with the stock in nature's plant library. A mechanism of systematically approaching and exploring the untouched plant genera needs to be designed.
疟疾对药物的耐药性不断增加，这就需要研发新的抗疟药物。抗疟草药及其活性化合物是最有希望的新抗疟药物来源。本研究旨在鉴定体外抗疟活性非常好（半数抑制浓度（IC）≤1μg/ml）的药用植物，并确定筛选其抗疟活性过程中的趋势。从文献数据库中检索了58篇英文发表的报告。筛选和数据提取由两名独立评审员进行。如果IC值分别<0.1μg/ml、0.1 - 1μg/ml、>1 - 5μg/ml和>5μg/ml，则将草药分类为非常好、好、中等和无活性。我们记录了属于254个属的752种药用植物。大多数植物来自非洲，其次是亚洲。传统上用于治疗疟疾是选择这些植物进行研究的最常见原因。约80%受试植物被报告无活性。在被鉴定为具有非常好至良好抗疟粗提物的植物中，有马达加斯加哈伦加那、非洲苦木和鸦胆子，而云杉皮克罗勒马、瓦加斯氏白坚木、德斯曼图姆白坚木和青蒿被报告具有具有非常好抗疟活性的单个化合物分离物。总之，与自然界植物库中的存量相比，目前评估的植物物种数量仍然很少。需要设计一种系统地接近和探索未涉及植物属的机制。
