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The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a β-catenin-dependent manner.

作者信息

Cao Li, Luo Fei-Fei, Huang Hong-Bin, Huang Tie-Jun, Hu Hao, Zheng Li-Sheng, Wang Jing, Peng Li-Xia, Qian Chao-Nan, Huang Bi-Jun

机构信息

School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou, People's Republic of China.

State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.

出版信息

Clin Transl Med. 2021 Feb;11(2):e311. doi: 10.1002/ctm2.311.

DOI:10.1002/ctm2.311
PMID:33634997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7851355/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7a/7851355/a972015518e4/CTM2-11-e311-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7a/7851355/159573a4aa23/CTM2-11-e311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7a/7851355/d377100835b8/CTM2-11-e311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7a/7851355/c90867d23989/CTM2-11-e311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7a/7851355/a972015518e4/CTM2-11-e311-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7a/7851355/159573a4aa23/CTM2-11-e311-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7a/7851355/d377100835b8/CTM2-11-e311-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7a/7851355/c90867d23989/CTM2-11-e311-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7a/7851355/a972015518e4/CTM2-11-e311-g004.jpg

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Front Oncol. 2022 Apr 14;12:868868. doi: 10.3389/fonc.2022.868868. eCollection 2022.
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Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook.

本文引用的文献

1
SRGN-TGFβ2 regulatory loop confers invasion and metastasis in triple-negative breast cancer.SRGN-TGFβ2调节环赋予三阴性乳腺癌侵袭和转移能力。
Oncogenesis. 2017 Jul 10;6(7):e360. doi: 10.1038/oncsis.2017.53.
2
Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis.细胞外丝甘蛋白聚糖以自分泌方式上调CD44受体，通过相互激活MAPK/β-连环蛋白轴来维持鼻咽癌细胞的自我更新。
Cell Death Dis. 2016 Nov 3;7(11):e2456. doi: 10.1038/cddis.2016.287.
3
Breast cancer stem cells: Multiple capacities in tumor metastasis.
细胞黏附分子在激素相关癌症中的作用机制：简要展望。
Front Endocrinol (Lausanne). 2022 Apr 7;13:865436. doi: 10.3389/fendo.2022.865436. eCollection 2022.
乳腺癌干细胞：肿瘤转移中的多种能力。
Cancer Lett. 2014 Jul 10;349(1):1-7. doi: 10.1016/j.canlet.2014.03.036. Epub 2014 Apr 12.
4
Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells.丝甘素与乳腺癌细胞侵袭性表型的促进有关。
PLoS One. 2013 Oct 31;8(10):e78157. doi: 10.1371/journal.pone.0078157. eCollection 2013.
5
Triple negative breast cancer - prognostic factors and survival.三阴性乳腺癌 - 预后因素与生存。
Radiol Oncol. 2011 Mar;45(1):46-52. doi: 10.2478/v10019-010-0054-4. Epub 2010 Dec 31.
6
CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?CD44：一个高表达的分子能使癌症起始细胞获益吗？
Nat Rev Cancer. 2011 Apr;11(4):254-67. doi: 10.1038/nrc3023. Epub 2011 Mar 10.
7
Estrogen receptor-negative and human epidermal growth factor receptor 2-negative breast cancer tissue have the highest Ki-67 labeling index and EGFR expression: gene amplification does not contribute to EGFR expression.雌激素受体阴性和人表皮生长因子受体2阴性的乳腺癌组织具有最高的Ki-67标记指数和表皮生长因子受体（EGFR）表达：基因扩增对EGFR表达无影响。
Oncol Rep. 2005 Aug;14(2):337-43.
8
Mutation of GATA3 in human breast tumors.人类乳腺肿瘤中GATA3的突变
Oncogene. 2004 Oct 7;23(46):7669-78. doi: 10.1038/sj.onc.1207966.