自调节的丝甘蛋白聚糖/CD44轴以β-连环蛋白依赖性方式驱动三阴性乳腺癌中的干性样表型。 - Suppr

The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a β-catenin-dependent manner.

作者信息

Cao Li, Luo Fei-Fei, Huang Hong-Bin, Huang Tie-Jun, Hu Hao, Zheng Li-Sheng, Wang Jing, Peng Li-Xia, Qian Chao-Nan, Huang Bi-Jun

机构信息

School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou, People's Republic of China.

State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.

出版信息

Clin Transl Med. 2021 Feb;11(2):e311. doi: 10.1002/ctm2.311.

DOI:10.1002/ctm2.311

PMID:33634997

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7851355/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa7a/7851355/159573a4aa23/CTM2-11-e311-g001.jpg

相似文献

The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a β-catenin-dependent manner.

Clin Transl Med. 2021 Feb;11(2):e311. doi: 10.1002/ctm2.311.

Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis.

Cell Death Dis. 2016 Nov 3;7(11):e2456. doi: 10.1038/cddis.2016.287.

Dual inhibition of Wnt and Yes-associated protein signaling retards the growth of triple-negative breast cancer in both mesenchymal and epithelial states.

Mol Oncol. 2018 Apr;12(4):423-440. doi: 10.1002/1878-0261.12167. Epub 2018 Feb 21.

Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression.

EBioMedicine. 2020 Apr;54:102717. doi: 10.1016/j.ebiom.2020.102717.

Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner.

Oncogene. 2017 Apr 27;36(17):2457-2471. doi: 10.1038/onc.2016.404. Epub 2016 Nov 7.

RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers.

Oncotarget. 2017 Jan 10;8(2):3072-3103. doi: 10.18632/oncotarget.13618.

Serglycin in human cancers.

Chin J Cancer. 2011 Sep;30(9):585-9. doi: 10.5732/cjc.011.10314.

Serglycin is involved in inflammatory response in articular mouse chondrocytes.

Biochem Biophys Res Commun. 2018 May 15;499(3):506-512. doi: 10.1016/j.bbrc.2018.03.178. Epub 2018 Mar 31.

Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer.

Exp Mol Med. 2020 May;52(5):832-842. doi: 10.1038/s12276-020-0440-y. Epub 2020 May 26.

Proteoglycan serglycin promotes non-small cell lung cancer cell migration through the interaction of its glycosaminoglycans with CD44.

J Biomed Sci. 2020 Jan 2;27(1):2. doi: 10.1186/s12929-019-0600-3.

引用本文的文献

CD44 and its implication in neoplastic diseases.

MedComm (2020). 2024 May 23;5(6):e554. doi: 10.1002/mco2.554. eCollection 2024 Jun.

Serglycin Is Involved in TGF-β Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue.

Front Oncol. 2022 Apr 14;12:868868. doi: 10.3389/fonc.2022.868868. eCollection 2022.

Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook.

Front Endocrinol (Lausanne). 2022 Apr 7;13:865436. doi: 10.3389/fendo.2022.865436. eCollection 2022.

本文引用的文献

SRGN-TGFβ2 regulatory loop confers invasion and metastasis in triple-negative breast cancer.

Oncogenesis. 2017 Jul 10;6(7):e360. doi: 10.1038/oncsis.2017.53.

Extracellular serglycin upregulates the CD44 receptor in an autocrine manner to maintain self-renewal in nasopharyngeal carcinoma cells by reciprocally activating the MAPK/β-catenin axis.

Cell Death Dis. 2016 Nov 3;7(11):e2456. doi: 10.1038/cddis.2016.287.

Breast cancer stem cells: Multiple capacities in tumor metastasis.

Cancer Lett. 2014 Jul 10;349(1):1-7. doi: 10.1016/j.canlet.2014.03.036. Epub 2014 Apr 12.

Serglycin is implicated in the promotion of aggressive phenotype of breast cancer cells.

PLoS One. 2013 Oct 31;8(10):e78157. doi: 10.1371/journal.pone.0078157. eCollection 2013.

Triple negative breast cancer - prognostic factors and survival.

Radiol Oncol. 2011 Mar;45(1):46-52. doi: 10.2478/v10019-010-0054-4. Epub 2010 Dec 31.

CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?

Nat Rev Cancer. 2011 Apr;11(4):254-67. doi: 10.1038/nrc3023. Epub 2011 Mar 10.

Estrogen receptor-negative and human epidermal growth factor receptor 2-negative breast cancer tissue have the highest Ki-67 labeling index and EGFR expression: gene amplification does not contribute to EGFR expression.

Oncol Rep. 2005 Aug;14(2):337-43.

Mutation of GATA3 in human breast tumors.

Oncogene. 2004 Oct 7;23(46):7669-78. doi: 10.1038/sj.onc.1207966.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a β-catenin-dependent manner.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

The autoregulatory serglycin/CD44 axis drives stemness-like phenotypes in TNBC in a β-catenin-dependent manner.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献