Berkelbach van der Sprenkel J W, Tulleken C A
Department of Neurosurgery, University Hospital, Utrecht, The Netherlands.
Stroke. 1988 Apr;19(4):503-6. doi: 10.1161/01.str.19.4.503.
The study of the relation between behavior, cerebral blood flow, and metabolism in animal models of cerebral ischemia has gained interest in the last 10 years. The most suitable models are those with the fewest side effects. One-sided blindness caused by decompression of the eye and coagulation of the optic nerve has been an inevitable side effect of transorbital occlusion of the middle cerebral artery. The postorbital technique is a new surgical approach to the middle cerebral artery that leaves the intraorbital structures intact. After resection of the postorbital processes and gentle retraction of the eye, the optic foramen is approached with the help of an operating microscope. This approach is possible because cats have no lateral bony orbital wall. A subperiostal approach to the optic foramen is made, after which the optic foramen is enlarged. Opening of the dura gives access to the middle cerebral artery in the same way as the transorbital approach. In this way, occlusion of the middle cerebral artery is possible with minimal impairment of vision.
在过去十年中，对脑缺血动物模型中行为、脑血流量和代谢之间关系的研究受到了关注。最合适的模型是副作用最少的模型。因眼球减压和视神经凝固导致的单侧失明一直是经眶闭塞大脑中动脉不可避免的副作用。眶后技术是一种针对大脑中动脉的新手术方法，可使眶内结构保持完整。切除眶后突起并轻柔牵拉眼球后，借助手术显微镜接近视神经孔。这种方法可行是因为猫没有外侧眶壁骨。采用骨膜下途径进入视神经孔，之后扩大视神经孔。打开硬脑膜后，与经眶途径一样可进入大脑中动脉。通过这种方式，在对视力影响最小的情况下实现大脑中动脉闭塞。
